ArticleJournal of neural transmission (Vienna, Austria : 1996)2020
Speech disorder and vocal tremor in postural instability/gait difficulty and tremor dominant subtypes of Parkinson's disease.
Article in Journal of neural transmission (Vienna, Austria : 1996), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 35 citations in OpenAlex.
- Speech and language biomarkers for Parkinson's disease prediction, early diagnosis and progression.NPJ Parkinson's disease · 2025Review
- Speech subtypes are associated with worsened tremor and axial symptoms in Parkinson's disease patients.Clinical parkinsonism & related disorders · 2025Article
- "Does speech in patients with different Parkinson's disease subtypes decline over time?"Clinical parkinsonism & related disorders · 2025Article
- Is self-perception related to speech perceptual analysis measures in early- and late-onset Parkinson's disease?Dementia & neuropsychologia · 2025Article
- Sex Differences in the Speech of Persons With and Without Parkinson's Disease.American journal of speech-language pathology · 2024Article
- Speech and gait abnormalities in motor subtypes of de-novo Parkinson's disease.CNS neuroscience & therapeutics · 2023Article
- Laryngeal symptoms related to motor phenotypes in Parkinson's disease: A systematic review.Laryngoscope investigative otolaryngology · 2023Review
- Parkinson's disease patients with freezing of gait have more severe voice impairment than non-freezers during "ON state".Journal of neural transmission (Vienna, Austria : 1996) · 2022Article
- Distinct patterns of speech disorder in early-onset and late-onset de-novo Parkinson's disease.NPJ Parkinson's disease · 2021Article
- Reciprocal Influence of Mobility and Speech-Language: Advancing Physical Therapy and Speech Therapy Cotreatment and Collaboration for Adults With Neurological Conditions.Physical therapy · 2021Article
- Self-perceptions of speech, voice, and swallowing in motor phenotypes of Parkinson's disease.Clinical parkinsonism & related disorders · 2020Article
- Associations of non-motor symptoms with perceptual speech impairments in Parkinson's disease.Frontiers in neurologyArticle
- Speech Characteristics Across Motor Subtypes of Parkinson's Disease.International journal of language & communication disordersArticle
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hypokinetic dysarthria is a multidimensional impairment affecting all main speech subsystems with variable patterns and severity across individual Parkinson's disease (PD) patients. We can thus assume that inter-individual abnormal speech patterns are related to the various clinical subtypes of PD with different prominent motor symptoms. The aim of this cross-sectional study was to compare speech disorder between patients with the postural instability/gait difficulty (PIGD) and tremor-dominant (TD) motor phenotypes of PD. Speech samples were acquired from a total of 63 participants, including 21 PIGD patients, 21 TD patients, and 21 healthy controls. Quantitative acoustic vocal assessment of 12 unique speech dimensions related to phonation, vocal tremor, oral diadochokinesis, articulation, prosody and speech timing was performed. Speech impairment was more pronounced in the PIGD group than in the TD group, with an area under the curve of 0.76. Patients in the PIGD group manifested abnormalities in pitch breaks, articulatory decay, decreased rate of follow-up speech segments and inappropriate silences, apart from monopitch and irregular AMR that were affected in TD group as well. An abnormal vocal tremor was present in only 10% of PD patients, with no differences between the PD phenotypes. We found a correlation between non-motor symptom severity and speech timing (r = - 0.40, p = 0.009). The present study demonstrates that speech disorder reflects the underlying motor phenotypes. Vocal tremor appeared to be an isolated phenomenon that does not share similar pathophysiology with limb tremor.
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