Trial reportJournal of thrombosis and thrombolysis2021
Circadian variations in pathogenesis of ST-segment elevation myocardial infarction: an optical coherence tomography study.
Trial report in Journal of thrombosis and thrombolysis, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- Insomnia-Associated Circadian and Thrombotic Alterations Coincide with Morning Cardiac Vulnerability.ACS pharmacology & translational science · 2026Article
- Severe Renal Colic as a Trigger of Coronary Thrombosis on Plaque Erosion.JACC. Case reports · 2026Article
- Sex differences in coronary artery disease.Naunyn-Schmiedeberg's archives of pharmacology · 2026Review
- Research progress on macrophage regulation of atherosclerosis.Frontiers in cardiovascular medicine · 2026Review
- Erosion of the Atheroma: Wicked T Cells at the Culprit Site.Current atherosclerosis reports · 2024Review
- Circadian rhythm pattern of symptom onset in patients with ST-segment elevation myocardial infarction in the Chinese population.Frontiers in cardiovascular medicine · 2024Article
- Association of the time of day of peak physical activity with cardiovascular mortality: Findings from the UK Biobank study.Chronobiology international · 2023Article
- Culprit Lesion Morphology on Optical Coherence Tomography in ST-elevation Myocardial Infarction vs Non ST-elevation Myocardial Infarction - A Systematic Review of 7526 Patients.Journal of the Saudi Heart Association · 2023Review
- Circadian Variations and Associated Factors in Patients with Ischaemic Heart Disease.International journal of environmental research and public health · 2022Article
- Role of Intracoronary Imaging in Acute Coronary Syndromes.US cardiology · 2022Review
- Precision Phenomapping of Acute Coronary Syndromes to Improve Patient Outcomes.Journal of clinical medicine · 2021Article
- Atherothrombosis in Acute Coronary Syndromes-From Mechanistic Insights to Targeted Therapies.Cells · 2021Review
- Plaque Erosion: A Distinctive Pathological Mechanism of Acute Coronary Syndrome.Frontiers in cardiovascular medicine · 2021Review
Corrections and comments
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Authors and funding
18 authors at 15 institutions in 7 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Previous studies have reported a circadian variation in the onset of ST-segment elevation myocardial infarction (STEMI). However, underlying mechanisms for the circadian variation have not been fully elucidated. We investigated the relationship between onset of STEMI and the underlying pathology using optical coherence tomography (OCT). Patients with a diagnosis of STEMI were selected from a multicenter OCT registry. Patients were divided into 4 groups based on the estimated time of onset (00:00-05:59, 06:00-11:59, 12:00-17:59, or 18:00-23:59). Underlying pathologies of MI (plaque rupture, plaque erosion, and calcified plaque) were compared among the 4 groups. Among 648 patients, plaque rupture was diagnosed in 386 patients (59.6%), plaque erosion in 197 patients (30.4%), and calcified plaque in 65 patients (10.0%). A marked circadian variation was detected in the incidence of plaque rupture with a peak at 09:00, whereas it was not evident in plaque erosion or calcified plaque. The probability of plaque rupture significantly increased in the periods of 06:00-11:59 [odds ratio (OR) 2.13, 95% confidence interval (CI) 1.30-3.49, p = 0.002] and 12:00-17:59 (OR 2.10, 95% CI 1.23-3.58, p = 0.005), compared to the period of 00:00-05:59. This circadian pattern was observed only during weekdays (p = 0.010) and it was not evident during the weekend (p = 0.742). Plaque rupture occurred most frequently in the morning and this circadian variation was evident only during weekdays. Acute MI caused by plaque rupture may be related to catecholamine surge.
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