Evidence map›Paper›PMID 32651855›Full record

SynthesisNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2021

Meta-analysis of the association between CHCHD10 Pro34Ser variant and the risk of amyotrophic lateral sclerosis.

Baiyuan Yang, Chenghui Yang, Junwei Ren, Chengqing Zhong, Keting Liu, Liusha Zhao, Li Li, Han Wang, Mingling Zhu, Zhenfang Lin

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 91% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Baiyuan Yang *Department of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Chenghui Yang *Department of Psychosomatic Medicine, Sichuan Academy of Medical Science & Sichuan Provincial People's Hospital, 32# West. Section 2, 1st RingRoad, Chengdu, 610072, Sichuan Province, China.
Junwei Ren *Department of Neurology, Fuling Central Hospital of Chongqing City, No.2, Gaosuntang Road, Fuling District, Chongqing, 408000, China.
Chengqing ZhongDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Keting LiuDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Liusha ZhaoDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Li LiDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Han WangDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Mingling ZhuDepartment of Neurology, Chengdu Seventh People's Hospital, 1188 Shuangxing Avenue, Shuangliu District, Chengdu, 610213, Sichuan Province, China.
Zhenfang LinDepartment of Neurology, Affiliated Sichuan Provincial Rehabilitation Hospital of Chengdu University of TCM, 81, Ba Yi Road, Wenjiang, Chengdu, 611135, Sichuan Province, China. 1326581972@qq.com.ORCID http://orcid.org/0000-0002-4328-6438
Seventh People's Hospital of Shanghai · CNFuling Center Hospital of Chongqing · CNSecond Affiliated Hospital of Chengdu University of Traditional Chinese · CNSichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital · CN

Funding

Sichuan application basic research project 20YYJC0146
6 · The paper itself

Abstract

backgroundAmyotrophic lateral sclerosis (ALS), one of the motor neuron diseases, appears to be caused by genetic and environmental risk factors. However, the influence of Pro34Ser variant of CHCHD10 gene in increasing risk of ALS remains indeterminate. This study conducted a meta-analysis to establish the association between Pro34Ser variant of CHCHD10 gene and risk of ALS.

methodsPubMed, Web of Science, and Embase databases were systematically searched for genome-wide association studies or case-control studies published up to March 28, 2020, on the association between Pro34Ser variant and risk of ALS. Data from eligible studies were extracted and analyzed.

resultsTwelve case-control studies involving 7442 patients with sporadic ALS and 75,371 controls were analyzed. The Pro34Ser variant was not associated with increased risk of ALS disease based on fixed-effects meta-analysis (Pro34Ser-positive vs Pro34Ser-negative: OR 1.23, 95% CI 0.90 to 1.69, P = 0.201).

conclusionExisting evidence suggests that Pro34Ser variant in CHCHD10 is not associated with risk of ALS, particularly in Caucasian participants. However, our results ought to be validated using large, well-designed studies, especially in Asian and African populations.

Indexed as

Amyotrophic Lateral SclerosisAsian PeopleCase-Control StudiesGenome-Wide Association StudyHumansMitochondrial ProteinsWhite PeopleCHCHD10 protein, humanMitochondrial ProteinsAmyotrophic lateral sclerosisCHCHD10Meta-analysisPro34SerVariant

Identifiers

PMID32651855
OpenAlexW3042171950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.