Evidence map›Paper›PMID 32651851›Full record

ArticleEndocrine2020

Gluten intake and risk of thyroid peroxidase autoantibodies in the Diabetes Autoimmunity Study In the Young (DAISY).

Jacqueline A Gardner, Randi K Johnson, Fran Dong, Michelle Hoffman, Andrea K Steck, Brigitte I Frohnert, Marian Rewers, Jill M Norris

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Endocrine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 85% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jacqueline A Gardner *Department of Epidemiology, Colorado School of Public Health, Aurora, CO, USA.
Randi K Johnson *Division of Bioinformatics and Personalized Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
Fran DongBarbara Davis Center for Diabetes, Aurora, CO, USA.
Michelle HoffmanBarbara Davis Center for Diabetes, Aurora, CO, USA.
Andrea K SteckBarbara Davis Center for Diabetes, Aurora, CO, USA.
Brigitte I FrohnertBarbara Davis Center for Diabetes, Aurora, CO, USA.
Marian RewersBarbara Davis Center for Diabetes, Aurora, CO, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO, USA. jill.norris@cuanschutz.edu.ORCID http://orcid.org/0000-0001-8674-2598
Sansum Diabetes Research Institute · USColorado School of Public Health · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Natural History of Pre-Diabetic Autoimmunity (DAISY)R01DK032493 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI REWERS, MARIAN J · 1986 to 2024
$9.3M
Nutrigenetics & -genomics of Vitamin D and Omega-3 Fatty Acids in Type 1 DiabetesR01DK104351 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI NORRIS, JILL M · 2014 to 2018
$2.9M
NIDDK NIH HHS R01 DK032493NIDDK NIH HHS R01 DK104351
6 · The paper itself

Abstract

purposeAutoimmune diseases co-occur, perhaps due to common risk factors. The age at gluten introduction and gluten intake in early childhood has been associated with the autoimmunity preceding celiac disease (CD) and type-1 diabetes (T1D). We explored their associations with the development of thyroid autoimmunity.

methodsDAISY has prospectively followed children at increased risk for T1D and CD since 1993. During follow-up, 107 children developed thyroid autoimmunity, defined as positivity for autoantibodies against thyroid peroxidase on at least two study visits. Age at gluten introduction was ascertained from food history interviews every 3 months until 15 months of age. Gluten intake (g/day) at age 1-2 years was estimated using a food frequency questionnaire.

resultsFrom multivariable Cox regression, there was no association between the age of gluten introduction nor the amount of gluten intake and development of thyroid autoimmunity. However, females (hazard ratio = 2.19, 95% CI: 1.46, 3.27) and cases of islet autoimmunity (HR = 2.20, 95% CI: 1.39, 3.50) were significantly more likely to develop thyroid autoimmunity, while exposure to environmental tobacco smoke decreased the risk (HR = 0.46, 95% CI: 0.30, 0.71).

conclusionsNeither the age of gluten introduction nor the amount of gluten consumed in early childhood is associated with risk of thyroid autoimmunity.

Indexed as

Celiac DiseaseDiabetes Mellitus, Type 1AutoantibodiesAutoimmunityChildChild, PreschoolFemaleGlutensHumansInfantIodide PeroxidasePeroxidaseRisk FactorsAutoantibodiesGlutensIodide PeroxidasePeroxidaseEnvironmental tobacco smokeGlutenInfant dietThyroid autoimmunityThyroid peroxidase

Identifiers

PMID32651851
PMCPMC7584755
OpenAlexW3041269031

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.