Evidence map›Paper›PMID 32651807›Full record

SynthesisHeart failure reviews2021

Effect of ivabradine on exercise capacity in individuals with heart failure with preserved ejection fraction.

Lino Sérgio Rocha Conceição, Caroline Gois, Raiane Eunice Santos Fernandes, Diego Santos Souza, Miburge Bolivar Gois Júnior, Vitor Oliveira Carvalho

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Heart failure reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 8 citations in OpenAlex.

  1. Guideline
  2. Pooled it
  3. Article
  4. Review
  5. Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Lino Sérgio Rocha ConceiçãoDepartment of Physical Therapy and Post-Graduate Program in Health Sciences, Federal University of Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, SE, Brazil. linosergiorocha@gmail.com.ORCID 0000-0002-9738-7613
Caroline GoisDepartment of Physical Therapy and Post-Graduate Program in Health Sciences, Federal University of Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, SE, Brazil.
Raiane Eunice Santos FernandesDepartment of Physical Therapy and Post-Graduate Program in Health Sciences, Federal University of Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, SE, Brazil.
Diego Santos SouzaDepartment of Anesthesiology, University of Arizona, Tucson, AZ, USA.
Miburge Bolivar Gois JúniorDepartment of Physical Therapy and Post-Graduate Program in Health Sciences, Federal University of Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, SE, Brazil.
Vitor Oliveira CarvalhoDepartment of Physical Therapy and Post-Graduate Program in Health Sciences, Federal University of Sergipe - UFS, Rua Cláudio Batista, s/n. Bairro Sanatório, Aracaju, Sergipe, SE, Brazil.
Universidade Federal de Sergipe · BRUniversidade de São Paulo · BRUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The prevalence of heart failure with preserved ejection fraction (HFpEF) is about 30-75% of the patients living with heart failure. A hallmark symptom of these patients is exercise intolerance. Ivabradine can, eventually, increase exercise capacity by heart rate control. However, clinical trials show conflicting results about the effects of ivabradine on exercise capacity, an important prognostic variable. The aim of this study was to investigate the effects of ivabradine on exercise capacity in individuals with HFpEF. This study was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement and supplemented by guidance from the Cochrane Collaboration Handbook for Systematic Reviews of Interventions. For the meta-analysis, a forest plot was used to graphically present the effect sizes and the 95% CIs. Four randomized controlled trials were included. Ivabradine did not change exercise capacity expressed by peak VO

Indexed as

Heart FailureExercise ToleranceHeart RateHumansIvabradineStroke VolumeIvabradineExercise toleranceHeart failureIvabradineMeta-analysis

Identifiers

PMID32651807
OpenAlexW3041886768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.