ArticleEnvironmental science and pollution research international2020
Biosynthesized silver nanoparticles regulate the iron status in the spleen of Plasmodium chabaudi-infected mice.
Article in Environmental science and pollution research international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 13 citations in OpenAlex.
- Surface-modified nanocarriers in the design of targeted drug delivery systems for parasitic diseases: a comprehensive review.BMC chemistry · 2026Review
- Antibacterial activity of epigallocatechin gallate againstFrontiers in veterinary science · 2026Article
- A histomorphometric study to evaluate the therapeutic effects of biosynthesized silver nanoparticles on the kidneys infected withOpen life sciences · 2024Article
- Pharmacological Effects of Biosynthesis Silver Nanoparticles UtilizingInternational journal of nanomedicine · 2024Article
- Biosynthesized nanosilver as anti-oxidant, anti-apoptotic and anti-inflammatory agent againstSaudi journal of biological sciences · 2021Article
- Medicinal plants as a fight against murine blood-stage malaria.Saudi journal of biological sciences · 2021Review
- Histopathologic effect and immunomodulatory ofInnate immunityArticle
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Malaria is a dangerous disease affecting millions around the globe. Biosynthesized nanoparticles are used against a variety of diseases including malaria worldwide. Here, silver nanoparticles (AgNPs) synthesized from the leaf extracts of Indigofera oblongifolia have been used in the treatment of mice infected with Plasmodium chabaudi to evaluate the expression of iron regulatory genes in the spleen. Infrared spectroscopy was used to identify the expected classes of compounds in the extract. AgNPs were able to decrease the parasitemia nearly similar to the used reference drug, chloroquine. In addition, AgNPs significantly decreased the spleen index after infection. Moreover, the iron distribution was increased after the treatment. Finally, AgNPs could regulate the mice spleen iron regulatory genes, Lipocalin 2 (Lcn2), transferrin receptor 1 (TFR1) and hepcidin antimicrobial peptide (Hamp). Taken together, our findings indicate that AgNPs have antimalarial activity and can control the state of iron in spleen. We need further investigations to determine mechanisms of action of the AgNPs.
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Registered trials
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