Evidence map›Paper›PMID 32651770›Full record

ArticleJournal of ultrasound2021

Can strain US-elastography with strain ratio (SRE) improve the diagnostic accuracy in the assessment of breast lesions? Preliminary results.

Daniela Elia, Daniele Fresilli, Patrizia Pacini, Sara Cardaccio, Giorgia Polti, Olga Guiban, Ilaria Celletti, Eriselda Kutrolli, Carlo De Felice, Rossella Occhiato and 8 more

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In one paragraph

Article in Journal of ultrasound, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 2 institutions in 1 country.

Daniela EliaDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy. daelia6@gmail.com.
Daniele FresilliDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Patrizia PaciniDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Sara CardaccioDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Giorgia PoltiDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Olga GuibanDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Ilaria CellettiDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Eriselda KutrolliDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Carlo De FeliceDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Rossella OcchiatoDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Corrado De VitoDepartment of Public Health and Infectious Diseases, Sapienza University of Rome, Rome, Italy.
Maria Ida AmabileDepartment of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Alessandro De LucaDepartment of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Vito D'AndreaDepartment of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Massimo VergineDepartment of Surgical Sciences, Sapienza University of Rome, Rome, Italy.
Federica PediconiDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Ferdinando D'AmbrosioDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Vito CantisaniDepartment of Radiology, Oncology, and Anatomy Pathology, Policlinico Umberto I, University Sapienza of Rome, Rome, Italy.
Policlinico Umberto I · ITSapienza University of Rome · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the diagnostic value of strain ratio elastography (SRE), a semiquantitative elastosonographic method based on the displacement of the tissue from an external source (manual compression with the transducer), as compared and in combination with conventional ultrasound for the differentiation of breast lesions.

methodsOne hundred and eighty-two patients with breast lesions consecutively underwent B-mode, color Doppler US, and strain US-elastography. Each lesion was classified according to the BI-RADS lexicon by evaluating the size, the B-mode, and color Doppler features and then evaluated by SRE. Histology proven by biopsy was used as the gold standard and the patients with malignant lesions subsequently underwent operations. The diagnostic performance of each method was assessed with 2 × 2 contingency tables and ROC curve analysis. To maximize the SRE sensitivity and specificity, the SRE cut-off value was calculated using the Youden test.

resultsHistological examination revealed 66 benign and 116 malignant breast lesions. The conventional ultrasound showed sensitivity and specificity for the differentiation of benign and malignant lesions of 86.2% and 75.8%, respectively. Similar results were found for strain US-elastography with a cut-off of 2.49, with sensitivity and specificity of 89.7% and 72.7%, respectively. The association of conventional ultrasound with the SRE value increased the sensitivity (98.3%) but decreased the specificity compared with conventional US alone (63.6%).

conclusionStrain US-elastography can be associated with BI-RADS US examination. According to our preliminary results, it helped increase the sensitivity although it decreased the specificity. However, further multicenter studies on a larger population are warranted.

Indexed as

Elasticity Imaging TechniquesBreastDiagnosis, DifferentialFemaleHumansUltrasonography, MammaryBI-RADSBreast lesionsStrain ratioStrain US-elastographyUltrasound

Identifiers

PMID32651770
PMCPMC8137748
OpenAlexW3040858354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.