Evidence map›Paper›PMID 32651708›Full record

ArticleNeurosurgical review2021

Quality of life and olfactory function after suprasellar craniopharyngioma surgery-a single-center experience comparing transcranial and endoscopic endonasal approaches.

Sascha Marx, Ioanna Tsavdaridou, Sebastian Paul, Antje Steveling, Cornelia Schirmer, Marton Eördögh, Stephan Nowak, Marc Matthes, Ehab El Refaee, Steffen K Fleck and 5 more

Abstract readComparative Study
In one paragraph

Article in Neurosurgical review, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Endoscopic endonasal versus open approach for craniopharyngioma treatment: a systematic review of clinical characteristics.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sascha MarxDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany. marxs@uni-greifswald.de.ORCID http://orcid.org/0000-0002-6451-5404
Ioanna TsavdaridouDepartment of ENT, University Medicine Greifswald, Greifswald, Germany.
Sebastian PaulDepartment of ENT, University Medicine Greifswald, Greifswald, Germany.
Antje StevelingDepartment of Internal Medicine, University Medicine Greifswald, Greifswald, Germany.
Cornelia SchirmerDepartment of Internal Medicine, University Medicine Greifswald, Greifswald, Germany.
Marton EördöghDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Stephan NowakDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Marc MatthesDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Ehab El RefaeeDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Steffen K FleckDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Joerg BaldaufDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.
Markus M LerchDepartment of Internal Medicine, University Medicine Greifswald, Greifswald, Germany.
Andreas StahlDepartment of Ophthalmology, University Medicine Greifswald, Greifswald, Germany.
Werner HosemannDepartment of ENT, University Medicine Greifswald, Greifswald, Germany.
Henry W S SchroederDepartment of Neurosurgery, University Medicine Greifswald, Sauerbruchstraße, 17475, Greifswald, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The endoscopic endonasal approach to suprasellar craniopharyngiomas has become popular as alternative to transcranial approaches. However, the literature lacks data regarding quality of life and olfactory function. The assessment of the long-term quality of life and olfactory function of all patients harboring a suprasellar craniopharyngioma who underwent surgery in our department has been done. Patient characteristics and perioperative data were gathered in a prospectively maintained database. At the last follow-up visit, the olfactory function and the quality of life (ASBQ, SNOT-22) as well as visual and pituitary function were assessed. Thirteen and 17 patients underwent surgery via a transcranial (T) and endonasal (E) route, respectively. No differences were seen in ASBQ, SNOT-22, and olfactory function between T and E, but in E were more full-time worker and less obesity. CSF leaks occurred in 15% of T and 29% of E (p = 0.43). Patients from group E had a superior visual outcome which was most pronounced in the visual field. The degree of new anterior and posterior pituitary gland deficiency after surgery and in the follow-up was lower in group E. The general and sinonasal quality of life and the olfactory function are equal in E and T. E is associated with a superior visual outcome, lower rates of diabetes insipidus, and lower rates of obesity, but has a higher risk for postoperative CSF leaks.

Indexed as

Quality of LifeAdolescentAdultAgedAged, 80 and overChildChild, PreschoolCraniopharyngiomaCraniotomyFemaleFollow-Up StudiesHumansInfantMaleMiddle AgedNeuroendoscopyCraniopharyngiomaEndonasal approachLong-term follow-upOlfactory functionQuality of lifeSkull base tumorsTranscranial approach

Identifiers

PMID32651708
PMCPMC8121742

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.