ArticleJournal of assisted reproduction and genetics2020
Increase of leucocyte-derived extracellular traps (ETs) in semen samples from human acute epididymitis patients-a pilot study.
Article in Journal of assisted reproduction and genetics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 18 citations in OpenAlex.
- Extracellular Traps at the Crossroads of Immune Evasion and Antimicrobial Resistance: The Case ofInternational journal of molecular sciences · 2026Review
- Presence of neutrophil extracellular traps (NETs) in different types of human urinary tract infections (UTI). A pilot study.Frontiers in immunology · 2026Article
- The Dual Role of Macrophage Extracellular Traps in Host Defense and Disease: Mechanisms and Therapeutic Implications.Biomolecules · 2025Review
- A comparative study of the effects of the COVID-19 pandemic on semen quality based on a nationwide relaxation of COVID-19 restrictions in China at the end of 2022.Translational andrology and urology · 2025Article
- Extrusion of Neutrophil Extracellular Traps (NETs) Negatively Impacts Canine Sperm Functions: Implications in Reproductive Failure.International journal of molecular sciences · 2024Article
- MCT-DependentBiology · 2023Article
- Article
- Adverse Effects of Single Neutrophil Extracellular Trap-Derived Components on Bovine Sperm Function.Animals : an open access journal from MDPI · 2022Article
- The Impact of Bacteriocenoses on Sperm Vitality, Immunological and Oxidative Characteristics of Ram Ejaculates: Does the Breed Play a Role?Animals : an open access journal from MDPI · 2021Article
- The Immune System Throws Its Traps: Cells and Their Extracellular Traps in Disease and Protection.Cells · 2021Review
- Identification of Bacterial Profiles and Their Interactions with Selected Quality, Oxidative, and Immunological Parameters of Turkey Semen.Animals : an open access journal from MDPI · 2021Article
- Article
- The Role of TLR2 and TLR4 in Recognition and Uptake of the Apicomplexan ParasitePathogens (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo study the effector mechanism against pathogens of polymorphonuclear neutrophils (PMN) and macrophages, called ETosis, involving the release of extracellular traps (ETs) in patients with acute epididymitis. To assess the different ET phenotypes present in semen samples and to identify correlations between ETosis and clinical parameters. MATERIALS AND
methodsSamples from patients diagnosed with acute epididymitis were examined and compared with samples from uninfected controls. Biochemical analyses of seminal fluid included determination of peroxidase, α-glucosidase, fructose, and elastase levels. ETosis in semen was determined through presence of citrullinated histones, global histones, and extracellular DNA. Different ETosis phenotypes such as spread ETs, aggregated ETs, and diffuse ETs were identified by co-localisation of extruded DNA with myeloperoxidase and global histones. Anti-CD15
resultsRevealed a high number of ETs compared with the control group. The mean number of CD15
conclusionsThis work shows for the first time the presence of ETs and their components in semen from patients with acute epididymitis. The presence of infections is an important factor for induction of ETs in semen. Furthermore, the presence of ETosis in ejaculates is suggestive of developing infectious processes and might possibly have a diagnostic value.
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