Trial reportClinical research in cardiology : official journal of the German Cardiac Society2021
Automatic positive airway pressure for obstructive sleep apnea in heart failure with reduced ejection fraction.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 26 citations in OpenAlex.
- Identification of salivary lipid biomarkers for noninvasive diagnosis of reflux esophagitis via UHPLC-MS-based lipidomics.Metabolomics : Official journal of the Metabolomic Society · 2026Article
- Continuous positive airway pressure on left ventricular ejection fraction in obstructive sleep apnea and heart failure with reduced ejection fraction: a systematic review and meta-analysis.Sleep and biological rhythms · 2026Article
- Sleep apnea in patients with exacerbated heart failure and overweight.Sleep medicine: X · 2023Article
- Insights into the Interaction of Heart Failure with Preserved Ejection Fraction and Sleep-Disordered Breathing.Biomedicines · 2023Review
- Association between Obstructive Sleep Apnea and Heart Failure in Adults-A Systematic Review.Journal of clinical medicine · 2023Review
- Impact of sleep apnoea on 30 day hospital readmission rate and cost in heart failure with reduced ejection fraction.ESC heart failure · 2023Article
- Effects of sacubitril-valsartan on central and obstructive apneas in heart failure patients with reduced ejection fraction.Sleep & breathing = Schlaf & Atmung · 2023Article
- Low-Cost SpO2 Integrated Neonatal CPAP Device for Low Resource Setting.Medical devices (Auckland, N.Z.) · 2023Article
- Prevalence and predictors of sleep-disordered breathing in chronic heart failure: the SchlaHF-XT registry.ESC heart failure · 2022Article
- Sleep-Disordered Breathing Is Associated With Reduced Left Atrial Strain Measured by Cardiac Magnetic Resonance Imaging in Patients After Acute Myocardial Infarction.Frontiers in medicine · 2022Article
- Sleep apnea and pulmonary hypertension: connecting the dots.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2021Article
- Phrenic Nerve Stimulation Improves Physical Performance and Hypoxemia in Heart Failure Patients with Central Sleep Apnea.Journal of clinical medicine · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundModerate-to-severe obstructive sleep apnea (OSA) is highly prevalent in heart failure patients with reduced left ventricular ejection fraction (HFrEF), and is associated with worsening cardiac function and increased mortality.
objectivesThe automatic positive airway pressure (APAP) trial tested the impact of APAP treatment on changes for the pre-specified endpoints: changes in peak oxygen uptake (peak VO
methodsThis randomized, controlled pilot study included patients with chronic, stable HFrEF who had moderate-to-severe OSA. Patients were randomized 1:1 to either APAP (AutoSet™, ResMed) or nasal strips (control) for 6 months.
results76 patients have been randomized and 58 had complete data for final analysis. There was a statistically significant change in the APAP intervention arm for the primary endpoint percent-predicted peak VO
conclusionAPAP intervention was shown to significantly improve outcome compared to control group, represented in percent-predicted peak VO
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Registered trials
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