Trial reportEuropean journal of applied physiology2020
Intermittent versus continuous enteral nutrition attenuates increases in insulin and leptin during short-term bed rest.
Trial report in European journal of applied physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Continuous Versus Intermittent Feeding on Changes in Insulin Sensitivity During Bed-rest
Evaluation de l'efficacité du Support Nutritionnel entéral Intermittent Sur la défaillance d'Organes de Patients de réanimation Sous Ventilation assistée ENteral NUTrition - Continue Intermittent
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Clinical effects and safety of semi-solid feeds in tube-fed patients: a meta-analysis and systematic review.Frontiers in nutrition · 2024Pooled it
- Rationale and design of a PROBE trial comparing continuous enteral nutrition to time-restricted enteral nutrition in severe stroke.Stroke and vascular neurology · 2026Trial
- Does Intermittent Nutrition Enterally Normalise hormonal and metabolic responses to feeding in critically ill adults? The DINE-normal proof-of-concept study.Clinical nutrition (Edinburgh, Scotland) · 2025Trial
- Trial
- Which is better for glycemic control? bolus, intermittent (nocturnal pause) or continuous enteral feeding in septic critically ill patients.Science progressTrial
- Application of Short Peptide Enteral Nutrition in Mechanically Ventilated Critically Ill Children with Severe Pneumonia and Its Impact on Patient Recovery.Infection and drug resistance · 2025Article
- Circadian de(regulation) in physiology: implications for disease and treatment.Genes & development · 2024Review
- Article
- Article
- Nutrition support for critically ill patients during the COVID-19 pandemic: the Italian SIAARTI survey.Journal of anesthesia, analgesia and critical care · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare endocrine responses to intermittent vs continuous enteral nutrition provision during short-term bed rest.
methodsTwenty healthy men underwent 7 days of bed rest, during which they were randomized to receive enteral nutrition (47%E as carbohydrate, 34%E as fat, 16%E as protein and 3%E as fibre) in a continuous (CONTINUOUS; n = 10; 24 h day
resultsDuring bed rest, plasma leptin concentrations were elevated to a lesser extent with INTERMITTENT vs CONTINUOUS (iAUC: 0.42 ± 0.38 vs 0.95 ± 0.48 nmol L
conclusionIntermittent enteral nutrition attenuates the progressive rise in plasma leptin and insulinemia seen with continuous feeding during bed rest, suggesting that continuous feeding increases insulin requirements to maintain euglycemia. This raises the possibility that hepatic insulin sensitivity is impaired to a greater extent with continuous versus intermittent feeding during bed rest. To attenuate endocrine and metabolic changes with enteral feeding, an intermittent feeding strategy may, therefore, be preferable to continuous provision of nutrition. This trial was registered on clinicaltrials.gov as NCT02521025.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.