ArticleWorld journal of surgery2020
Predictive Value of the Age-Adjusted Charlson Comorbidity Index for Outcomes After Hepatic Resection of Hepatocellular Carcinoma.
Article in World journal of surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Predictive Ability of Comorbidity Indices for Surgical Morbidity and Mortality: a Systematic Review and Meta-analysis.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2023Pooled it
- Predictors of Postoperative Morbidity in Hepatic Hemangioma Surgery: A Single-Center Experience.Medicina (Kaunas, Lithuania) · 2026Article
- Article
- Age-Adjusted Charlson Comorbidities Index for Survival Prognosis in Laryngeal Squamous Cell Carcinoma Patients.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- Article
- Predictive Value of Age-Adjusted Charlson Comorbidity Index on Survival Outcomes of Hepatocellular Carcinoma Patients with Comorbidities Undergoing Radiofrequency Ablation.Journal of hepatocellular carcinoma · 2026Article
- Exploratory evaluation of combined handgrip strength and Age-Adjusted Charlson Comorbidity Index for prognosis in patients with primary liver cancer undergoing hepatectomy: a single-centre pilot study.Frontiers in medicine · 2026Article
- Deep learning model using contrast-enhanced CT imaging features and clinical variables to predict surgical risk after hepatic resection for hepatocellular carcinoma.Frontiers in oncology · 2026Article
- Radiotherapy for Liver-Confined Hepatocellular Carcinoma in Elderly Patients with Comorbidity.Cancers · 2025Article
- Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach.Journal of hepatocellular carcinoma · 2025Article
- Significance of Multidisciplinary Teams for Patients with Oral and Maxillofacial Surgical Diseases: An Observational Retrospective Study in a General Hospital in China.Journal of multidisciplinary healthcare · 2024Article
- Major hepatectomy in elderly patients: possible benefit from robotic platform utilization.Surgical endoscopy · 2023Article
- Development of a model based on the age-adjusted Charlson comorbidity index to predict survival for resected perihilar cholangiocarcinoma.World journal of gastrointestinal oncology · 2023Article
- Disparities in the first-ever diagnosed liver cancers between the emergency department and outpatient department in Taiwan: a population-based study.BMC public health · 2023Article
- A comprehensive preoperative predictive score for post-hepatectomy liver failure after hepatocellular carcinoma resection based on patient comorbidities, tumor burden, and liver function: the CTF score.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundThis study aimed to evaluate the impact of the age-adjusted Charlson comorbidity index (ACCI) on outcomes after hepatic resection for hepatocellular carcinoma (HCC).
methodsWe assessed 763 patients who underwent hepatic resection for HCC. The ACCI scores were categorized as follows: ACCI ≤ 5, ACCI = 6, and ACCI ≥ 7.
resultsA multivariate analysis showed that the odds ratios for postoperative complications in ACCI = 6 and ACCI ≥ 7 groups, with reference to ACCI ≤ 5 group, were 0.71 (p = 0.41) and 4.15 (p < 0.001), respectively. The hazard ratios for overall survival of ACCI = 6 and ACCI ≥ 7 groups, with reference to ACCI ≤ 5 group, were 1.52 (p = 0.023) and 2.45 (p < 0.001), respectively. The distribution of deaths due to HCC-related, liver-related, and other causes was 68.2%, 11.8%, and 20% in ACCI ≤ 5 group, 47.2%, 13.9%, and 38.9% in ACCI = 6 group, and 27.3%, 9.1%, and 63.6% in ACCI ≥ 7 group (p = 0.053; ACCI ≤ 5 vs. = 6, p = 0.19; ACCI = 6 vs. ≥ 7, p < 0.001; ACCI ≤ 5 vs. ≥ 7). In terms of the treatment for HCC recurrence in ACCI ≤ 5, ACCI = 6, and ACCI ≥ 7 groups, adaptation rate of surgical resection was 20.1%, 7.3%, and 11.1% and the rate of palliative therapy was 4.3%, 12.2%, and 22.2%, respectively.
conclusionsThe ACCI predicted the short-term and long-term outcomes after hepatic resection of HCC. These findings will help physicians establish a treatment strategy for HCC patients with comorbidities.
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