ReviewNature medicine2020
Extrapulmonary manifestations of COVID-19.
3 registry-linked trialsAbstract readReview
In one paragraph
Review in Nature medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 1,799 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
1,799citing papers in PubMed, 6 pooled it
69.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Epidemiology of Weaning From Invasive Mechanical Ventilation in COVID-19. Observational and Multicenter Study.
Effects of Immunomodulation With Interleukin-6 Antagonists on the Coagulation System in Critically-ill Covid-19 Patients
Karakteristik Dan Pengaruh Vaksinasi COVID-19 Terhadap Klinis Dan Kualitas Hidup Pasien Long COVID di RSUPN Dr. Cipto Mangunkusumo
Who cites it
1,799 citing papers in PubMed, 6 syntheses or guidelines pooled it, 3,268 citations in OpenAlex.
- Rhabdomyolysis Reported in Association with SARS-CoV-2 Infection and COVID-19 Vaccination: A Systematic Review.Medicina (Kaunas, Lithuania) · 2026Pooled it
- Impact of air pollution on COVID-19 severity: a systematic review of underlying biological mechanisms.European respiratory review : an official journal of the European Respiratory Society · 2025Pooled it
- Systemic cytokines drive conserved severity-associated myeloid responses across bacterial and viral infections.Communications biology · 2025Pooled it
- Post-COVID-19 Vaccination Meningitis and Meningoencephalitis: A Systematic Review of Case Series and Case Reports.The American journal of tropical medicine and hygiene · 2025Pooled it
- Cardiovascular outcomes in long COVID-19: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2025Pooled it
- Bone Mineral Density, Bone Biomarkers, and Joints in Acute, Post, and Long COVID-19: A Systematic Review.Viruses · 2024Pooled it
- Comorbidities increase the severity of COVID-19: an analysis and epidemiological study conducted in Algeria.The Libyan journal of medicine · 2026Article
- Management of long COVID-19 in children and adolescents: from diagnosis to therapeutically approaches.Annals of medicine · 2026Review
- Hitting Coronaviruses Where It Hurts: Antiviral Strategies Targeting Viral Proteins.ChemMedChem · 2026Review
- Pre-ECMO characteristics, organ dysfunction and exploratory mortality prediction in COVID-19 versus non-COVID-19 ARDS treated with veno-venous ECMO: a retrospective cohort study.BMC anesthesiology · 2026Article
- Spike Protein at the Crossroads of Long-COVID and Vaccine-Induced Immune Thrombotic Thrombocytopenia Syndromes: A Cardio-Hematological Perspective.Biomedicines · 2026Review
- Glucose metabolism across COVID-19 and long COVID: a longitudinal study.Journal of the Endocrine Society · 2026Article
- Microscopic giant platelets versus automated mean platelet volume for severity assessment in COVID-19.Medicine · 2026Article
- β-Cell Dysfunction in COVID-19 and Post-COVID Syndrome: Molecular Mechanisms Linking Inflammation, Oxidative Stress, and Insulin Secretion.International journal of molecular sciences · 2026Review
- The Unmet Need of Olfactory Testing in Inflammatory Disorders of the Upper Airways-An EAACI Position Paper.Allergy · 2026Review
- Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS-CoV-2 Infection.MedComm · 2026Article
- FGL-1 plasma levels correlate with markers of inflammation and severe disease during SARS-CoV-2 infection.Communications medicine · 2026Article
- Article
- Advancements in the study of gut microbiome in disease diagnosis.Antonie van Leeuwenhoek · 2026Review
- Detecting and Preventing Fraudulent Participation in Qualitative Research: Content Analysis of Two Multisite Studies.Journal of medical Internet research · 2026Article
1,739 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 10 institutions in 1 country.
Aakriti Gupta *Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0001-9103-9872
Mahesh V Madhavan *Division of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-7740-1481
Kartik Sehgal *Division of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.ORCID http://orcid.org/0000-0003-4391-6943
Nandini NairDivision of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Shiwani MahajanCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.ORCID http://orcid.org/0000-0002-5617-489X
Tejasav S SehrawatDivision of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.ORCID http://orcid.org/0000-0001-7346-5683
Behnood BikdeliDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Neha AhluwaliaDivision of Cardiology, Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
John C AusielloDivision of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Elaine Y WanDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Daniel E FreedbergDivision of Digestive and Liver Diseases, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Ajay J KirtaneClinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Sahil A ParikhDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Mathew S MaurerDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Anna S NordvigDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the NewYork-Presbyterian Hospital, New York, NY, USA.
Domenico AcciliDivision of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Joan M BathonDivision of Rheumatology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Sumit MohanDivision of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.ORCID http://orcid.org/0000-0002-5305-9685
Kenneth A BauerDivision of Hematology and Oncology, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Martin B LeonDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Harlan M KrumholzCenter for Outcomes Research and Evaluation, Yale New Haven Hospital, New Haven, CT, USA.ORCID http://orcid.org/0000-0003-2046-127X
Nir UrielDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
Mandeep R MehraDivision of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, MA, USA.
Mitchell S V ElkindDepartment of Neurology, Vagelos College of Physicians and Surgeons, Columbia University and the NewYork-Presbyterian Hospital, New York, NY, USA.ORCID http://orcid.org/0000-0003-2562-1156
Gregg W StoneClinical Trials Center, Cardiovascular Research Foundation, New York, NY, USA.
Allan SchwartzDivision of Cardiology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
David D HoAaron Diamond AIDS Research Center, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA.
John P BilezikianDivision of Endocrinology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, New York, NY, USA.
Donald W LandryDivision of Nephrology, Department of Medicine, NewYork-Presbyterian/Columbia University Irving Medical Center, New York, NY, USA. dwl1@cumc.columbia.edu.
Columbia University Irving Medical Center · USYale New Haven Hospital · USBeth Israel Deaconess Medical Center · USNewYork–Presbyterian Hospital · USAaron Diamond AIDS Research Center · USBrigham and Women's Hospital · USCardiovascular Institute of the South · USCardiovascular Research Foundation · USIcahn School of Medicine at Mount Sinai · USMayo Clinic in Arizona · US
Funding
Translational Biomarker Analytical Core (TBAC)P30DK063608 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Rebecca Anne Haeusler, Utpal Pajvani · 2003 to 2026
$36.7MPOSTDOCTORAL TRAINING IN CARDIOVASCULAR DISEASET32HL007854 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Marwah Abdalla, Michael Argenziano · 1996 to 2026
$14.7MInflammation and Cardiovascular Disease in Rheumatoid ArthritisR01AR050026 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BATHON, JOAN MARIE · 2004 to 2022
$9.7MTreatments Against RA and Effect on FDG PET CT: The TARGET TRIALU01AR068043 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI BATHON, JOAN MARIE, SOLOMON, DANIEL HAL · 2015 to 2021
$8.7MNEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M5/14 APOL1 Long-term Kidney Transplantation Outcomes Network (APOLLO) Clinical CenterU01DK116066 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Sumit Mohan, Deirdre Sawinski · 2017 to 2026
$2.5MUnderstanding the role of mitochondrial dysfunction in cardiac arrhythmias using a novel 3D panoramic optical mapping systemR01HL152236 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2020 to 2024
$2.0MIdentifying and exploring solutions to the ethical challenges of ApoL1 testing of donors with recent African ancestry through mixed methods research with stakeholdersR01MD014161 · NIMHD · WASHINGTON UNIVERSITY · PI DUBOIS, JAMES M, MOHAN, SUMIT · 2019 to 2021
$1.2MIncreasing Minority Population Awareness through Community Teaching for Improved Organ Donation (IMPACT for Improved Organ Donation)R01DK114893 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MOHAN, SUMIT · 2017 to 2021
$1.2MRole of Vascular Ion Channels in Heart Failure and Cardiovascular DiseasesK08HL122526 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2015 to 2019
$788kLoss of Gastrointestinal Colonization Resistance and Antibiotic-Resistant Infections in the Intensive Care UnitK23DK111847 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI FREEDBERG, DANIEL E. · 2017 to 2020
$608kElucidating the molecular mechanisms of cognitive decline in atrial fibrillationR03HL146881 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI WAN, ELAINE Y · 2019 to 2020
$162kNHLBI NIH HHS K08 HL122526NHLBI NIH HHS R01 HL152236NHLBI NIH HHS R03 HL146881NHLBI NIH HHS T32 HL007854NIAMS NIH HHS R01 AR050026NIAMS NIH HHS U01 AR068043NIDDK NIH HHS K23 DK111847NIDDK NIH HHS P30 DK063608NIDDK NIH HHS R01 DK114893NIDDK NIH HHS U01 DK116066NIMHD NIH HHS R01 MD014161NINDS NIH HHS T32 NS007153
Abstract
Although COVID-19 is most well known for causing substantial respiratory pathology, it can also result in several extrapulmonary manifestations. These conditions include thrombotic complications, myocardial dysfunction and arrhythmia, acute coronary syndromes, acute kidney injury, gastrointestinal symptoms, hepatocellular injury, hyperglycemia and ketosis, neurologic illnesses, ocular symptoms, and dermatologic complications. Given that ACE2, the entry receptor for the causative coronavirus SARS-CoV-2, is expressed in multiple extrapulmonary tissues, direct viral tissue damage is a plausible mechanism of injury. In addition, endothelial damage and thromboinflammation, dysregulation of immune responses, and maladaptation of ACE2-related pathways might all contribute to these extrapulmonary manifestations of COVID-19. Here we review the extrapulmonary organ-specific pathophysiology, presentations and management considerations for patients with COVID-19 to aid clinicians and scientists in recognizing and monitoring the spectrum of manifestations, and in developing research priorities and therapeutic strategies for all organ systems involved.
Indexed as
Organ SpecificityAdaptive ImmunityBetacoronavirusCoronavirus InfectionsCOVID-19Disease ProgressionEndothelium, VascularHumansInflammationPandemicsPneumonia, ViralRenin-Angiotensin SystemSARS-CoV-2ThrombosisVirus Internalization
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Read underepoch 390
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.