Trial reportMolecular psychiatry2021
Modifiable predictors of nonresponse to psychotherapies for late-life depression with executive dysfunction: a machine learning approach.
Trial report in Molecular psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- Machine learning in the prediction of treatment response for emotional disorders: A systematic review and meta-analysis.Clinical psychology review · 2025Pooled it
- Artificial intelligence in mental health care: a systematic review of diagnosis, monitoring, and intervention applications.Psychological medicine · 2025Pooled it
- Machine learning approaches in the therapeutic outcome prediction in major depressive disorder: a systematic review.Frontiers in psychiatry · 2025Pooled it
- Modifiable predictors of suicidal ideation during psychotherapy for late-life major depression. A machine learning approach.Translational psychiatry · 2021Trial
- Perceived Social Support and Interpersonal Functioning as Predictors of Treatment Response Among Depressed Older Adults.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2021Trial
- Targeting mechanisms of change as a path to precision psychotherapy for community settings.Psychotherapy research : journal of the Society for Psychotherapy Research · 2026Article
- A Scoping Review of Amenable Patient-Specific Predictors of Treatment Failure in the Treatment of Anxiety and Depressive Disorders.Clinical psychology in Europe · 2026Review
- Machine learning in mental health promotion for older adults: a scoping review.BMC geriatrics · 2026Article
- Associations Between Depression Severity, Antidepressant Use, and Metabolic Syndrome Components Among Chinese Adults: A Cross-Sectional Study Based on Historical Medical Records.Actas espanolas de psiquiatria · 2026Article
- Protocol for a randomized trial to predict the efficacy of cognitive and behavioral interventions for symptoms of depression.Frontiers in psychiatry · 2026Article
- Identifying Four Developmental Trajectories of Metabolic Syndrome and Their Influencing Factors: A Longitudinal Cohort Study of Railway Employees' Physical Examinations.International journal of endocrinology · 2025Article
- Breakthroughs and challenges for generating brain network-based biomarkers of treatment response in depression.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024Review
- Improving social reward responsivity and social connectedness in psychotherapies for late-life depression: Engage & Connect as an example.Psychiatry research · 2023Article
- Community Mobility and Depressive Symptoms During the COVID-19 Pandemic in the United States.JAMA network open · 2023Article
- A 50-state survey study of thoughts of suicide and social isolation among older adults in the United States.Journal of affective disorders · 2023Article
- Perception of Social Support and Cognitive Performance in Older Adults With Depression.JAMA network open · 2023Article
- Methodological and Quality Flaws in the Use of Artificial Intelligence in Mental Health Research: Systematic Review.JMIR mental health · 2023Review
- Association of 1-year change in neuroticism and 3-year change in cognitive performance among older depressed adults.International psychogeriatrics · 2022Observational
- Improving Interventions for Loneliness and Social Isolation in Late Life: The Potential Role of Positive Affect.The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
The study aimed to: (1) Identify distinct trajectories of change in depressive symptoms by mid-treatment during psychotherapy for late-life depression with executive dysfunction; (2) examine if nonresponse by mid-treatment predicted poor response at treatment end; and (3) identify baseline characteristics predicting an early nonresponse trajectory by mid-treatment. A sample of 221 adults 60 years and older with major depression and executive dysfunction were randomized to 12 weeks of either problem-solving therapy or supportive therapy. We used Latent Growth Mixture Models (LGMM) to detect subgroups with distinct trajectories of change in depression by mid-treatment (6th week). We conducted regression analyses with LGMM subgroups as predictors of response at treatment end. We used random forest machine learning algorithms to identify baseline predictors of LGMM trajectories. We found that ~77.5% of participants had a declining trajectory of depression in weeks 0-6, while the remaining 22.5% had a persisting depression trajectory, with no treatment differences. The LGMM trajectories predicted remission and response at treatment end. A random forests model with high prediction accuracy (80%) showed that the strongest modifiable predictors of the persisting depression trajectory were low perceived social support, followed by high neuroticism, low treatment expectancy, and low perception of the therapist as accepting. Our results suggest that modifiable risk factors of early nonresponse to psychotherapy can be identified at the outset of treatment and addressed with targeted personalized interventions. Therapists may focus on increasing meaningful social interactions, addressing concerns related to treatment benefits, and creating a positive working relationship.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.