ArticleScientific reports2020
Transcriptomic analysis of regulatory pathways involved in female reproductive physiology of Rhodnius prolixus under different nutritional states.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Loss of vitellogenin receptor function results in yolk depletion, virome expansion, and reduced bacterial load within the oocytes of Rhodnius prolixus.BMC biology · 2026Article
- Lipids in Insect Reproduction: Where, How, and Why.Advances in experimental medicine and biology · 2026Review
- Characteristics of the Insulin-like Peptide Genes and Their Roles in the Ovarian Development ofInsects · 2025Article
- Octopamine is required for successful reproduction in the classical insect model, Rhodnius prolixus.PloS one · 2024Article
- Current Status of Omics Studies Elucidating the Features of Reproductive Biology in Blood-Feeding Insects.Insects · 2023Review
- Effects of mating on female reproductive physiology in the insect model, Rhodnius prolixus, a vector of the causative parasite of Chagas disease.PLoS neglected tropical diseases · 2023Article
- Knockdown of carnitine palmitoyltransferase I (CPT1) reduces fat body lipid mobilization and resistance to starvation in the insect vectorFrontiers in physiology · 2023Article
- Global characterization of gene expression in the brain of starved immature Rhodnius prolixus.PloS one · 2023Article
- Functional characterization of maternally accumulated hydrolases in the mature oocytes of the vectorFrontiers in physiology · 2023Article
- A critical role for ecdysone response genes in regulating egg production in adult female Rhodnius prolixus.PloS one · 2023Article
- Massive invasion on a Triatominae insectarium (Hemiptera: Heteroptera: Reduviidae) by Attagenus fasciatus (Thunberg, 1795) (Coleoptera: Dermestidae: Attageninae).Revista da Sociedade Brasileira de Medicina Tropical · 2023Article
- Malpighian tubules ofFrontiers in insect science · 2023Review
- Crosstalk between Nutrition, Insulin, Juvenile Hormone, and Ecdysteroid Signaling in the Classical Insect Model,International journal of molecular sciences · 2022Article
- Role of Methoprene-tolerant in the regulation of oogenesis in Dipetalogaster maxima.Scientific reports · 2022Article
- Article
- A fat body transcriptome analysis of the immune responses of Rhodnius prolixus to artificial infections with bacteria.Parasites & vectors · 2022Article
- Dynamics of maternal gene expression in Rhodnius prolixus.Scientific reports · 2022Article
- Bicaudal C is required for the function of the follicular epithelium during oogenesis in Rhodnius prolixus.Development genes and evolution · 2021Article
- Fluid Secretion by Malpighian Tubules ofFrontiers in endocrinology · 2021Review
- Regulation of a Trehalose-Specific Facilitated Transporter (TRET) by Insulin and Adipokinetic Hormone inFrontiers in physiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The triatomine Rhodnius prolixus, a vector of the etiological agent of Chagas disease, has long been used as model to understand important aspects of insect physiology. Despite this history, the impact of the nutritional state on regulatory pathways associated with reproductive performance in triatomines has never been studied. The insulin-like peptide/target of rapamycin (ILP/ToR) signaling pathway is typically responsible for detecting and interpreting nutrient levels. Here, we analyzed transcriptomes from the central nervous system, fat bodies and ovaries of adult females in unfed and fed conditions, with a focus on the ILP/ToR signaling. The results show an up-regulation of transcripts involved in ILP/ToR signaling in unfed insects. However, we demonstrate that this signaling is only activated in tissues from fed insects. Moreover, we report that FoxO (forkhead box O) factor, which regulates longevity via ILP signaling, is responsible for the up-regulation of transcripts related with ILP/ToR signaling in unfed insects. As a consequence, we reveal that unfed females are in a sensitized state to respond to an increase of ILP levels by rapidly activating ILP/ToR signaling. This is the first analysis that correlates gene expression and protein activation of molecules involved with ILP/ToR signaling in R. prolixus females in different nutritional states.
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