Evidence map›Paper›PMID 32651405›Full record

ArticleScientific reports2020

Klf9 is a key feedforward regulator of the transcriptomic response to glucocorticoid receptor activity.

Ian Gans, Ellen I Hartig, Shusen Zhu, Andrea R Tilden, Lucie N Hutchins, Nathaniel J Maki, Joel H Graber, James A Coffman

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Sex-specific differences in zebrafish brains.Biology of sex differences · 2022
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  18. Zebrafish Mutant Lines Reveal the Interplay betweenInternational journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Ian GansMDI Biological Laboratory, Salisbury Cove, ME, USA.
Ellen I HartigMDI Biological Laboratory, Salisbury Cove, ME, USA.
Shusen ZhuMDI Biological Laboratory, Salisbury Cove, ME, USA.
Andrea R TildenColby College, Waterville, ME, USA.
Lucie N HutchinsMDI Biological Laboratory, Salisbury Cove, ME, USA.
Nathaniel J MakiMDI Biological Laboratory, Salisbury Cove, ME, USA.
Joel H GraberMDI Biological Laboratory, Salisbury Cove, ME, USA.
James A CoffmanMDI Biological Laboratory, Salisbury Cove, ME, USA. jcoffman@mdibl.org.
Mount Desert Island Biological Laboratory · USUniversity of Maine · USColby College · US

Funding

The Maine Biomedical Research Network (INBRE)P20GM103423 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI Dustin Lynn Updike · 2012 to 2026
$60.0M
Understanding the role of thyroid hormone signaling during axolotl limb regenerationP20GM104318 · NIGMS · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI DRUMMOND, IAIN A. · 2013 to 2023
$23.0M
Gene regulatory circuitry underlying the dynamic control of glucocorticoid signalingR03HD099468 · NICHD · MOUNT DESERT ISLAND BIOLOGICAL LAB · PI COFFMAN, JAMES A · 2019 to 2020
$166k
NICHD NIH HHS R03 HD099468NIGMS NIH HHS P20 GM103423NIGMS NIH HHS P20 GM104318
6 · The paper itself

Abstract

The zebrafish has recently emerged as a model system for investigating the developmental roles of glucocorticoid signaling and the mechanisms underlying glucocorticoid-induced developmental programming. To assess the role of the Glucocorticoid Receptor (GR) in such programming, we used CRISPR-Cas9 to produce a new frameshift mutation, GR

Indexed as

CRISPR-Cas SystemsFrameshift MutationTranscriptomeAnimalsExonsGene DeletionGene Expression RegulationHomozygoteHumansHydrocortisoneInflammationKruppel-Like Transcription FactorsLarvaMutationReceptors, GlucocorticoidReceptors, MineralocorticoidHydrocortisoneKlf9 protein, zebrafishKruppel-Like Transcription FactorsReceptors, GlucocorticoidReceptors, MineralocorticoidZebrafish Proteins

Identifiers

PMID32651405
PMCPMC7351738
OpenAlexW3041555636

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.