Evidence map›Paper›PMID 32651395›Full record

ArticleScientific reports2020

Glomerular endothelial cell heterogeneity in Alport syndrome.

Hasmik Soloyan, Matthew Thornton, Valentina Villani, Patrick Khatchadourian, Paolo Cravedi, Andrea Angeletti, Brendan Grubbs, Roger De Filippo, Laura Perin, Sargis Sedrakyan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
11.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 79 citations in OpenAlex.

  1. Article
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  8. AdvancedFrontiers in immunology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Hasmik SoloyanGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA.
Matthew ThorntonMaternal Fetal Medicine Division, University of Southern California, Los Angeles, USA.
Valentina VillaniGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA.
Patrick KhatchadourianGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA.
Paolo CravediDivision of Nephrology, Department of Medicine, Icahn School of Medicine At Mount Sinai, New York, NY, USA.
Andrea AngelettiNephrology Dialysis and Renal Transplantation Unit, S. Orsola University Hospital, Bologna, Italy.
Brendan GrubbsMaternal Fetal Medicine Division, University of Southern California, Los Angeles, USA.
Roger De FilippoGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA.
Laura PerinGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA.
Sargis SedrakyanGOFARR Laboratory for Organ Regenerative Research and Cell Therapeutics in Urology, Division of Urology, The Saban Research Institute, Children's Hospital Los Angeles, University of Southern California, 4661 Sunset Boulevard MS #35, Los Angeles, CA, 90027, USA. ssedrakyan@chla.usc.edu.
University of Southern California · USChildren's Hospital of Los Angeles · USIcahn School of Medicine at Mount Sinai · US

Funding

Multiphoton microscope replacement for USC shared resourceS10OD021833 · OD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI PETI-PETERDI, JANOS · 2017 to 2017
$600k
NIH HHS S10 OD021833
6 · The paper itself

Abstract

Glomerular endothelial cells (GEC) are a crucial component of the glomerular physiology and their damage contributes to the progression of chronic kidney diseases. How GEC affect the pathology of Alport syndrome (AS) however, is unclear. We characterized GEC from wild type (WT) and col4α5 knockout AS mice, a hereditary disorder characterized by progressive renal failure. We used endothelial-specific Tek-tdTomato reporter mice to isolate GEC by FACS and performed transcriptome analysis on them from WT and AS mice, followed by in vitro functional assays and confocal and intravital imaging studies. Biopsies from patients with chronic kidney disease, including AS were compared with our findings in mice. We identified two subpopulations of GEC (dim

Indexed as

AdolescentAdultAnimalsApelinBiopsyCell SeparationDisease ProgressionEndothelial CellsFlow CytometryGene Expression ProfilingGenes, ReporterGlomerulosclerosis, Focal SegmentalHumansInflammationKidney GlomerulusMaleApelinApln protein, mouse

Identifiers

PMID32651395
PMCPMC7351764
OpenAlexW3041904418

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.