ArticleNature communications2020
Value and choice as separable and stable representations in orbitofrontal cortex.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Disgust-reduction evaluative conditioning (DREC) and tDCS in contamination-based OCD: a randomized controlled trial.BMC psychiatry · 2026Trial
- Article
- Population geometries in frontal cortex coordinate value-based decisions.bioRxiv : the preprint server for biology · 2026Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- A ventral tegmental area GABAergic projection to the ventral pallidum regulates value-based decision making in mice.bioRxiv : the preprint server for biology · 2026Article
- A posture subspace in the primary motor cortex.Neuron · 2025Article
- Neural coding of choice and outcome are modulated by uncertainty in orbitofrontal but not secondary motor cortex.Nature communications · 2025Article
- Neuronal Activity in Orbitofrontal Cortex during Trinary Choices under Risk.bioRxiv : the preprint server for biology · 2025Article
- Cognitive processes are disentangled at cortex-wide scales.bioRxiv : the preprint server for biology · 2025Article
- Adaptive reward representations integrate expected uncertainty signals in orbitofrontal cortex.Science advances · 2025Article
- Continuous sensorimotor transformation enhances robustness of neural dynamics to perturbation in macaque motor cortex.Nature communications · 2025Article
- Semi-orthogonal subspaces for value mediate a binding and generalization trade-off.Nature neuroscience · 2024Article
- Rational inattention in neural coding for economic choice.bioRxiv : the preprint server for biology · 2024Article
- A computational mechanism of cue-stimulus integration for pain in the brain.Science advances · 2024Article
- Anatomical correlates of apathy and impulsivity co-occurrence in early Parkinson's disease.Journal of neurology · 2024Article
- Orthogonal neural encoding of targets and distractors supports multivariate cognitive control.Nature human behaviour · 2024Article
- Behavioral read-out from population value signals in primate orbitofrontal cortex.Nature neuroscience · 2023Article
- Article
- Semi-orthogonal subspaces for value mediate a tradeoff between binding and generalization.ArXiv · 2023Article
- Dorsal raphe neurons signal integrated value during multi-attribute decision-making.bioRxiv : the preprint server for biology · 2023Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Value-based decision-making requires different variables-including offer value, choice, expected outcome, and recent history-at different times in the decision process. Orbitofrontal cortex (OFC) is implicated in value-based decision-making, but it is unclear how downstream circuits read out complex OFC responses into separate representations of the relevant variables to support distinct functions at specific times. We recorded from single OFC neurons while macaque monkeys made cost-benefit decisions. Using a novel analysis, we find separable neural dimensions that selectively represent the value, choice, and expected reward of the present and previous offers. The representations are generally stable during periods of behavioral relevance, then transition abruptly at key task events and between trials. Applying new statistical methods, we show that the sensitivity, specificity and stability of the representations are greater than expected from the population's low-level features-dimensionality and temporal smoothness-alone. The separability and stability suggest a mechanism-linear summation over static synaptic weights-by which downstream circuits can select for specific variables at specific times.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.