ArticleNature communications2020
Phasic dopamine reinforces distinct striatal stimulus encoding in the olfactory tubercle driving dopaminergic reward prediction.
Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed.
- Thalamocortical bursts encode reward contingencies and drive associative learning.Nature communications · 2026Article
- Neuromodulator Dynamics Underlying Associative Learning in the Ventral Striatum's Olfactory Tubercle.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Neurons embedded in loop-like motifs act as central hubs for brain-wide integration.The Journal of physiology · 2026Article
- Implementation of active methodologies: a six-phase instructional design model from a neuroeducational perspective.Frontiers in human neuroscience · 2026Article
- Deletion of NPAS4 in olfactory bulb principal neurons alters E/I balance and impairs decoding of chemically similar odour molecules.The Journal of physiology · 2026Article
- A hardwired neural circuit for temporal difference learning.bioRxiv : the preprint server for biology · 2025Article
- A tactile discrimination task to study neuronal dynamics in freely-moving mice.Nature communications · 2025Article
- Out of the single-neuron straitjacket: Neurons within assemblies change selectivity and their reconfiguration underlies dynamic coding.The Journal of physiology · 2025Article
- Dopaminergic signaling to ventral striatum neurons initiates sniffing behavior.Nature communications · 2025Article
- The learning primacy hypothesis of dopamine: reconsidering dopamine's dual functions.Frontiers in cellular neuroscience · 2025Review
- Computational analyses to reveal the key determinants of the high malignancy level of cholangiocarcinoma.Journal of translational internal medicine · 2024Article
- Article
- Anterior Olfactory Cortices Differentially Transform Bottom-Up Odor Signals to Produce Inverse Top-Down Outputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Integration of rate and phase codes by hippocampal cell-assemblies supports flexible encoding of spatiotemporal context.Nature communications · 2024Article
- Smoking-Related Increases in Alcohol Outcomes and Preliminary Evidence for the Protective Effect of a Functional Nicotine Receptor Gene (CHRNA5) Variant on Alcohol Consumption in Individuals Without Alcohol Use Disorder.The international journal of neuropsychopharmacology · 2024Article
- Oxytocin induces the formation of distinctive cortical representations and cognitions biased toward familiar mice.Nature communications · 2024Article
- Connecting the dots in the zona incerta: A study of neural assemblies and motifs of inter-area coordination in mice.iScience · 2024Article
- Endogenous opioids in the olfactory tubercle and their roles in olfaction and quality of life.Frontiers in neural circuits · 2024Review
- Circuit dynamics of the olfactory pathway during olfactory learning.Frontiers in neural circuits · 2024Review
- Connectivity of the olfactory tubercle: inputs, outputs, and their plasticity.Frontiers in neural circuits · 2024Review
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The learning of stimulus-outcome associations allows for predictions about the environment. Ventral striatum and dopaminergic midbrain neurons form a larger network for generating reward prediction signals from sensory cues. Yet, the network plasticity mechanisms to generate predictive signals in these distributed circuits have not been entirely clarified. Also, direct evidence of the underlying interregional assembly formation and information transfer is still missing. Here we show that phasic dopamine is sufficient to reinforce the distinctness of stimulus representations in the ventral striatum even in the absence of reward. Upon such reinforcement, striatal stimulus encoding gives rise to interregional assemblies that drive dopaminergic neurons during stimulus-outcome learning. These assemblies dynamically encode the predicted reward value of conditioned stimuli. Together, our data reveal that ventral striatal and midbrain reward networks form a reinforcing loop to generate reward prediction coding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.