ArticleProceedings of the National Academy of Sciences of the United States of America2020
Chemosensory mechanisms of host seeking and infectivity in skin-penetrating nematodes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
- Neuronally sensed oxygen drives behavior and development in human-infective, skin-penetrating nematodes.bioRxiv : the preprint server for biology · 2026Article
- Peptidomic Identification of Behaviour-Modulating Putative Neuropeptides inInternational journal of molecular sciences · 2026Article
- Transgenesis and targeted mutagenesis in the human-parasitic nematodeFrontiers in parasitology · 2026Review
- TheJournal of nematology · 2026Review
- Strongyloides species exhibit distinct behaviors on the skin of different mammals.BMC infectious diseases · 2025Article
- Large-scale protein interactome reveals lineage-specific genes driving plant-parasitic nematode adaptive innovations.Science advances · 2025Article
- Dopamine signaling drives skin invasion by human-infective nematodes.Nature communications · 2025Article
- Evolution of lateralized gustation in nematodes.eLife · 2025Article
- Carbon dioxide shapes parasite-host interactions in a human-infective nematode.Current biology : CB · 2025Article
- Thermosensory behaviors of the free-living life stages of Strongyloides species support parasitism in tropical environments.PLoS neglected tropical diseases · 2024Article
- Neurogenesis in Caenorhabditis elegans.Genetics · 2024Review
- Thermosensory behaviors of the free-living life stages ofbioRxiv : the preprint server for biology · 2024Article
- The generation of stable transgenic lines in the human-infective nematode Strongyloides stercoralis.G3 (Bethesda, Md.) · 2024Article
- Carbon dioxide shapes parasite-host interactions in a human-infective nematode.bioRxiv : the preprint server for biology · 2024Article
- Review
- Invade or die: behaviours and biochemical mechanisms that drive skin penetration inPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Insight into the emerging insect to human pathogenFrontiers in microbiology · 2024Article
- Astacin metalloproteases in human-parasitic nematodes.Advances in parasitology · 2024Review
- A high-throughput sensory assay for parasitic and free-living nematodes.Integrative biology : quantitative biosciences from nano to macro · 2023Article
- StringentJournal of nematology · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Approximately 800 million people worldwide are infected with one or more species of skin-penetrating nematodes. These parasites persist in the environment as developmentally arrested third-stage infective larvae (iL3s) that navigate toward host-emitted cues, contact host skin, and penetrate the skin. iL3s then reinitiate development inside the host in response to sensory cues, a process called activation. Here, we investigate how chemosensation drives host seeking and activation in skin-penetrating nematodes. We show that the olfactory preferences of iL3s are categorically different from those of free-living adults, which may restrict host seeking to iL3s. The human-parasitic threadworm
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.