ArticleJournal of neurology, neurosurgery, and psychiatry2020
Apathy, but not depression, predicts all-cause dementia in cerebral small vessel disease.
Article in Journal of neurology, neurosurgery, and psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Treatment of apathy in stroke patients: a systematic review.Frontiers in neurology · 2025Pooled it
- Machine Learning for Dementia Prediction: A Systematic Review and Future Research Directions.Journal of medical systems · 2023Pooled it
- Apathy and Depression Impact on Cognitive Decline: Neuropsychological Specificities across Neurodegenerative Diseases.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2026Article
- Depressive Symptoms Profiles and Cognitive Outcomes After Stroke.Brain and behavior · 2025Article
- Examining apathy prevalence and associated factors among older adults after the Great East Japan Earthquake: a mixed-methods study.BMC geriatrics · 2025Article
- The challenge of exploring neuropsychiatric and cognitive symptoms after spontaneous intracerebral hemorrhage.European journal of neurology · 2025Article
- Meso-cortical pathway damage in cognition, apathy and gait in cerebral small vessel disease.Brain : a journal of neurology · 2024Article
- Evaluation of apathy in non-clinical populations: validation, psychometric properties, and normative data of the Italian version of Apathy-Motivation Index (AMI).Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- The importance of a multidimensional approach to the preclinical study of major depressive disorder and apathy.Emerging topics in life sciences · 2022Article
- Automatic segmentation of white matter hyperintensities in routine clinical brain MRI by 2D VB-Net: A large-scale study.Frontiers in aging neuroscience · 2022Article
- Evidence and implications of abnormal predictive coding in dementia.Brain : a journal of neurology · 2021Review
- Apathy after stroke: Diagnosis, mechanisms, consequences, and treatment.International journal of stroke : official journal of the International Stroke Society · 2021Review
- Individual markers of cerebral small vessel disease and domain-specific quality of life deficits.Brain and behavior · 2021Article
- Specific Dimensions of Depression Have Different Associations With Cognitive Decline in Older Adults With Type 2 Diabetes.Diabetes care · 2021Article
- Plasma Total Tau and Neurobehavioral Symptoms of Cognitive Decline in Cognitively Normal Older Adults.Frontiers in psychology · 2021Article
- Cognitive Reserve, Leisure Activity, and Neuropsychological Profile in the Early Stage of Cognitive Decline.Frontiers in aging neuroscience · 2020Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveTo determine whether apathy or depression predicts all-cause dementia in small vessel disease (SVD) patients.
methodsAnalyses used two prospective cohort studies of SVD: St. George's Cognition and Neuroimaging in Stroke (SCANS; n=121) and Radboud University Nijmegen Diffusion Tensor and Magnetic Resonance Cohort (RUN DMC; n=352). Multivariate Cox regressions were used to predict dementia using baseline apathy and depression scores in both datasets. Change in apathy and depression was used to predict dementia in a subset of 104 participants with longitudinal data from SCANS. All models were controlled for age, education and cognitive function.
resultsBaseline apathy scores predicted dementia in SCANS (HR 1.49, 95% CI 1.05 to 2.11, p=0.024) and RUN DMC (HR 1.05, 95% CI 1.01 to 1.09, p=0.007). Increasing apathy was associated with dementia in SCANS (HR 1.53, 95% CI 1.08 to 2.17, p=0.017). In contrast, baseline depression and change in depression did not predict dementia in either dataset. Including apathy in predictive models of dementia improved model fit.
conclusionsApathy, but not depression, may be a prodromal symptom of dementia in SVD, and may be useful in identifying at-risk individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.