ArticleRadiation oncology (London, England)2020
Dosimetric effects of adaptive prostate cancer radiotherapy in an MR-linac workflow.
Article in Radiation oncology (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 35 citations in OpenAlex.
- Clinical application of MR-Linac in tumor radiotherapy: a systematic review.Radiation oncology (London, England) · 2023Pooled it
- AI-based detection of temporal changes in MR-Linac images acquired during routine prostate radiotherapy.Physics and imaging in radiation oncology · 2026Article
- Clinical indicators for dose re-optimization in magnetic resonance-guided online adaptive radiotherapy for prostate cancer.Physics and imaging in radiation oncology · 2026Article
- Magnetic Resonance Guided Radiation Therapy (MRgRT) Prostate Motion and Margins.Journal of medical radiation sciences · 2026Article
- Continuing Professional Development - Radiation Therapy.Journal of medical radiation sciences · 2026Article
- Long-term patient experience with online MR-guided radiotherapy: adaptive versus non-adaptive workflow.Frontiers in oncology · 2026Article
- Associations of static anatomical geometry with planned dosimetric endpoints in prostate radiotherapy: a multicenter study.Frontiers in oncology · 2026Article
- Development and evaluation of deep learning models for estimating the organ at-risk dose constraint from two-dimensional cine magnetic resonance imaging scans during irradiation.Journal of applied clinical medical physics · 2025Article
- A cone-beam computed tomography based workflow for online adaptive ultra-hypofractionated radiotherapy of prostate cancer.Physics and imaging in radiation oncology · 2025Article
- Analysis of intra-fractional surface motion during adaptive radiation therapy and relation of internal vs. external position for prostate cancer.Radiation oncology (London, England) · 2025Article
- Magnetic resonance guided adaptive post prostatectomy radiotherapy: Accumulated dose comparison of different workflows.Journal of applied clinical medical physics · 2024Article
- Evaluation of Unity 1.5 T MR-linac plan quality in patients with prostate cancer.Journal of applied clinical medical physics · 2023Article
- Adaptation Time as a Determinant of the Dosimetric Effectiveness of Online Adaptive Radiotherapy for Bladder Cancer.Cancers · 2023Article
- Evaluation of MRI-only based online adaptive radiotherapy of abdominal region on MR-linac.Journal of applied clinical medical physics · 2023Article
- Inter- and intrafraction dose variations in robotic stereotactic body radiation therapy (SBRT) for perihilar cholangiocarcinoma in the prospective phase I STRONG trial.Frontiers in oncology · 2023Article
- Outcome of the first 200 patients with prostate cancer treated with MRI-Linac at Assuta MC.Frontiers in oncology · 2023Article
- Impact of intrafraction motion in pancreatic cancer treatments with MR-guided adaptive radiation therapy.Frontiers in oncology · 2023Article
- Impact of intrafraction changes in delivered dose of the day for prostate cancer patients treated with stereotactic body radiotherapy via MR-Linac.Technical innovations & patient support in radiation oncology · 2022Article
- Magnetic resonance imaging-guided radiotherapy for intermediate- and high-risk prostate cancer: Trade-off between planning target volume margin and online plan adaption.Physics and imaging in radiation oncology · 2022Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe purpose was to evaluate the dosimetric effects in prostate cancer treatment caused by anatomical changes occurring during the time frame of adaptive replanning in a magnetic resonance linear accelerator (MR-linac) workflow.
methodsTwo MR images (MR1 and MR2) were acquired with 30 min apart for each of the 35 patients enrolled in this study. The clinical target volume (CTV) and organs at risk (OARs) were delineated based on MR1. Using a synthetic CT (sCT), ultra-hypofractionated VMAT treatment plans were created for MR1, with three different planning target volume (PTV) margins of 7 mm, 5 mm and 3 mm. The three treatment plans of MR1, were recalculated onto MR2 using its corresponding sCT. The dose distribution of MR2 represented delivered dose to the patient after 30 min of adaptive replanning, omitting motion correction before beam on. MR2 was registered to MR1, using deformable registration. Using the inverse deformation, the structures of MR1 was deformed to fit MR2 and anatomical changes were quantified. For dose distribution comparison the dose distribution of MR2 was warped to the geometry MR1.
resultsThe mean center of mass vector offset for the CTV was 1.92 mm [0.13 - 9.79 mm]. Bladder volume increase ranged from 12.4 to 133.0% and rectum volume difference varied between -10.9 and 38.8%. Using the conventional 7 mm planning target volume (PTV) margin the dose reduction to the CTV was 1.1%. Corresponding values for 5 mm and 3 mm PTV margin were 2.0% and 4.2% respectively. The dose to the PTV and OARs also decreased from D1 to D2, for all PTV margins evaluated. Statistically significant difference was found for CTV D
conclusionsA target underdosage caused by anatomical changes occurring during the reported time frame for adaptive replanning MR-linac workflows was found. Volume changes in both bladder and rectum caused large prostate displacements. This indicates the importance of thorough position verification before treatment delivery and that the workflow needs to speed up before introducing margin reduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.