Evidence map›Paper›PMID 32650731›Full record

ArticleBMC geriatrics2020

Third follow-up of the Cardiovascular Risk Factors, Aging and Dementia (CAIDE) cohort investigating determinants of cognitive, physical, and psychosocial wellbeing among the oldest old: the CAIDE85+ study protocol.

Mariagnese Barbera, Jenni Kulmala, Inna Lisko, Eija Pietilä, Anna Rosenberg, Ilona Hallikainen, Merja Hallikainen, Tiina Laatikainen, Jenni Lehtisalo, Elisa Neuvonen and 6 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC geriatrics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03938727 (Cardiovascular Risk Factors, Aging and Dementia), which is not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03938727 completednot on this map

Cardiovascular Risk Factors, Aging and Dementia (III Follow-up)

TypeobservationalSponsorUniversity of Eastern FinlandRan2019 to 2021Enrolled195ConditionsDementia
3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 14 citations in OpenAlex.

  1. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 4 countries.

Mariagnese BarberaInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland. mariagnese.barbera@uef.fi.ORCID 0000-0002-8983-1294
Jenni KulmalaPublic Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Inna LiskoDivision of Clinical Geriatrics, Center for Alzheimer Research, Care Sciences and Society (NVS), Karolinska Institutet, Karolinska Universitetssjukhuset, Karolinska Vägen 37 A, QA32, Stockholm, Sweden.
Eija PietiläInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Anna RosenbergInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Ilona HallikainenInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Merja HallikainenInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Tiina LaatikainenPublic Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Jenni LehtisaloInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Elisa NeuvonenInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Minna RusanenInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Hilkka SoininenInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Jaakko TuomilehtoPublic Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Tiia NganduPublic Health Promotion Unit, Finnish Institute for Health and Welfare, P.O. Box 30, 00271, Helsinki, Finland.
Alina SolomonInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
Miia KivipeltoInstitute of Clinical Medicine, Department of Neurology, University of Eastern Finland, P.O. Box 1627, 70211, Kuopio, Finland.
University of Eastern Finland · FIKarolinska University Hospital · SEUniversity of Helsinki · FI

Funding

Academy of Finland 287490Academy of Finland 319318
6 · The paper itself

Abstract

backgroundThe oldest old is the fastest growing age group worldwide and the most prone to severe disability, especially in relation to loss of cognitive function. Improving our understanding of the predictors of cognitive, physical and psychosocial wellbeing among the oldest old can result in substantial benefits for the individuals and for the society as a whole. The Cardiovascular Risk Factors, Aging and Dementia (CAIDE) study investigated risk factors and determinants of cognitive impairment in a population-based longitudinal cohort, which was first examined between 1972 and 1992, when individuals were in their midlife, and re-assessed in 1998 and 2005-2009. Most of the study participants are currently aged 85 years or older. We aim to re-examine the cohort's survivors and gain further insights on the mechanisms underlying both cognitive and overall healthy ageing at old age.

methodsCAIDE85+ is the third follow-up of the CAIDE study participants. All individuals still alive and living in the Kuopio and Joensuu areas of Eastern Finland, from the original CAIDE cohort (two random samples, N = 2000 + ~ 900), will be invited to a re-examination. The assessment includes self-reported data related to basic demographics and lifestyle, as well as psychosocial and physical health status. Cognitive and physical evaluations are also conducted. Blood biomarkers relevant for dementia and ageing are assessed. Primary outcomes are the measurements related to cognition and daily life functioning (CERAD, Trail Making Test-A, Letter-Digit Substitution Test, Clinical Dementia Rating and Activities of Daily Living). Secondary endpoints of the study are outcomes related to physical health status, psychosocial wellbeing, as well as age-related health indicators. DISCUSSION: Through a follow-up of more than 40 years, CAIDE85+ will provide invaluable information on the risk and protective factors that contribute to cognitive and physical health, as well as ageing and longevity. STUDY REGISTRATION: The present study protocol has been registered at https://clinicaltrials.gov/ (registration nr NCT03938727 , date 03.05.2019).

Indexed as

Cardiovascular DiseasesCognitive DysfunctionDementiaActivities of Daily LivingAged, 80 and overCognitionFinlandFollow-Up StudiesHeart Disease Risk FactorsHumansRisk FactorsAgeingCAIDECognitive declineDementiaDisabilityLongevityLongitudinal cohort studyMidlife risk factorsPhysical functioningProtocol

Identifiers

PMID32650731
PMCPMC7350760
OpenAlexW3041017853

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.