Evidence map›Paper›PMID 32650583›Full record

ReviewMolecules (Basel, Switzerland)2020

RNA Granules: A View from the RNA Perspective.

Siran Tian, Harrison A Curnutte, Tatjana Trcek

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 82 citations in OpenAlex.

  1. Article
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  3. Review
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  11. How germ granules promote germ cell fate.Nature reviews. Genetics · 2024
    Review
  12. Enigmatic Pachytene PIWI-Interacting RNAs.Genome biology and evolution · 2024
    Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Siran TianHomewood Campus, Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0003-3295-6472
Harrison A CurnutteHomewood Campus, Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0002-3445-425X
Tatjana TrcekHomewood Campus, Department of Biology, Johns Hopkins University, 3400 N. Charles Street, Baltimore, MD 21218, USA.ORCID 0000-0003-4405-8733
Johns Hopkins University · US

Funding

mRNA assembly in Drosophila germ granulesR35GM142737 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Tatjana Trcek · 2021 to 2026
$2.6M
Mechanisms of mRNA localization to Drosophila germ granulesR00HD088675 · NICHD · JOHNS HOPKINS UNIVERSITY · PI TRCEK, TATJANA · 2019 to 2021
$733k
NICHD NIH HHS R00 HD088675NIGMS NIH HHS R35 GM142737NIH HHS NICHD K99HD088675
6 · The paper itself

Abstract

RNA granules are ubiquitous. Composed of RNA-binding proteins and RNAs, they provide functional compartmentalization within cells. They are inextricably linked with RNA biology and as such are often referred to as the hubs for post-transcriptional regulation. Much of the attention has been given to the proteins that form these condensates and thus many fundamental questions about the biology of RNA granules remain poorly understood: How and which RNAs enrich in RNA granules, how are transcripts regulated in them, and how do granule-enriched mRNAs shape the biology of a cell? In this review, we discuss the imaging, genetic, and biochemical data, which have revealed that some aspects of the RNA biology within granules are carried out by the RNA itself rather than the granule proteins. Interestingly, the RNA structure has emerged as an important feature in the post-transcriptional control of granule transcripts. This review is part of the Special Issue in the Frontiers in RNA structure in the journal Molecules.

Indexed as

AnimalsCytoplasmic GranulesHumansRibonucleoproteinsRNARibonucleoproteinsRNAgerm granulesp-bodiesRNA granulesRNA phase separationRNA-RNA interactionsRNA secondary structureRNA self-assemblystress granules

Identifiers

PMID32650583
PMCPMC7397151
OpenAlexW3041115542

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.