SynthesisDrug and alcohol dependence2020
Socioeconomic marginalization and opioid-related overdose: A systematic review.
Synthesis in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 113 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
113 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Patient-related risk factors for new persistent opioid use after surgery among opioid-naïve individuals in the United States: a systematic review and meta-analysis.Pain medicine (Malden, Mass.) · 2026Pooled it
- Social and economic determinants of drug overdose deaths: a systematic review of spatial relationships.Social psychiatry and psychiatric epidemiology · 2024Pooled it
- Psychosocial factors associated with overdose subsequent to Illicit Drug use: a systematic review and narrative synthesis.Harm reduction journal · 2024Pooled it
- Predictors of fatal and nonfatal overdose after prescription of opioids for chronic pain: a systematic review and meta-analysis of observational studies.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2023Pooled it
- The impact of relaxing restrictions on take-home doses during the COVID-19 pandemic on program effectiveness and client experiences in opioid agonist treatment: a mixed methods systematic review.Substance abuse treatment, prevention, and policy · 2023Pooled it
- Homelessness and health-related outcomes: an umbrella review of observational studies and randomized controlled trials.BMC medicine · 2022Pooled it
- Mental disorder and opioid overdose: a systematic review.Social psychiatry and psychiatric epidemiology · 2022Pooled it
- Differential Impacts of Methadone and Buprenorphine/Naloxone on Pain-Related Outcomes Among People With Non-Heroin Opioid Use Disorder: Secondary Analyses From a Pragmatic Canadian Multisite Trial.Drug and alcohol review · 2026Trial
- Factors Associated With Opioid-Involved Overdose: Descriptive Data From a Randomized Controlled Trial Evaluating Extended-Release Buprenorphine for Perinatal Opioid Use Disorder.Substance use & addiction journal · 2026Trial
- Perception and Correlates of Opioid Overdose Risk Among Overdose Survivors Who Use Nonprescribed Opioids in San Francisco and Boston.Substance use & addiction journal · 2024Trial
- Psychopathy Facets Differentially Predict Drug- and Alcohol-Related Problems Following Violent Injury.Behavioral sciences (Basel, Switzerland) · 2026Article
- Death anxiety and death-related depression in opioid use disorder: relationships with suicidal ideation, impulsivity, and psychological resilience.BMC psychiatry · 2026Article
- Childhood social characteristics and drug-related mortality by age 41: a register-based study of Finnish birth cohorts 1982-2004.European journal of public health · 2026Article
- Substance use treatment and overdose patterns in high and low social vulnerability counties: a trends analysis in New Jersey from 2014-2022.Addictive behaviors reports · 2026Article
- The All-Payer Claims Database After the Gobeille Supreme Court Decision: Assessing the Impact on Fatal Opioid-Related Overdose Research.Health services research · 2026Article
- Socioeconomic inequities in drug poisoning deaths in Canada.Canadian journal of public health = Revue canadienne de sante publique · 2026Article
- Implementation evaluation of a Massachusetts pilot program designed to reduce overdose deaths among Black and Latino men returning from incarceration.Frontiers in public health · 2026Article
- "Because we're the experts": centering the expertise of people who use drugs to identify and propose solutions for overdose prevention.Harm reduction journal · 2025Article
- Patterns of Non-fatal Overdose and Injection-Related Bacterial Infections During Pregnancy and the Postpartum Year Among New York State Residents.Maternal and child health journal · 2025Article
- A Risk Taxonomy and Reflection Tool for Large Language Model Adoption in Public Health.Proceedings of the ACM on human-computer interaction · 2025Article
53 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
backgroundSocioeconomic marginalization (SEM) is an important but under-explored determinant of opioid overdose with important implications for health equity and associated public policy initiatives. This systematic review synthesizes evidence on the role of SEM in both fatal and non-fatal overdose among people who use opioids.
methodsStudies published between January 1, 2000 and March 31, 2018 were identified through searching electronic databases, citations, and by contacting experts. The titles, abstracts, citation information, and descriptor terms of citations were screened by two team members. Data were synthesized using the lumping technique.
resultsA total of 37 studies met inclusion criteria and were included in the review, with 34 of 37 finding a significant association between at least one socioeconomic factor and overdose. The included studies contained variables related to eight socioeconomic factors: criminal justice system involvement, income, employment, social support, health insurance, housing/homelessness, education, and composite measures of socio-economic status. Most studies found associations in the hypothesized direction, whereby increased SEM was associated with a higher rate or increased likelihood of the overdose outcome measured. The review revealed an underdeveloped evidence base.
conclusionsNearly all reviewed studies found a connection between a socioeconomic variable and overdose, but more research is needed with an explicit focus on SEM, using robust and nuanced measures that capture multiple dimensions of disadvantage, and collect data over time to better inform decision making around opioid overdose.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.