ArticleNeurobiology of aging2020
The relationship between DNA methylation in neurotrophic genes and age as evidenced from three independent cohorts: differences by delirium status.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Brain-derived neurotrophic factor (BDNF) epigenomic modifications and brain-related phenotypes in humans: A systematic review.Neuroscience and biobehavioral reviews · 2023Pooled it
- Pathophysiology and biomarkers of delirium in older adults-Narrative review.Zeitschrift fur Gerontologie und Geriatrie · 2026Review
- Epigenetic signals associated with delirium replicated across four independent cohorts.Translational psychiatry · 2024Article
- Alterations in Neurotrophins in Alcohol-Addicted Patients during Alcohol Withdrawal.Brain sciences · 2024Review
- An Overview of the Epigenetic Modifications in the Brain under Normal and Pathological Conditions.International journal of molecular sciences · 2024Review
- NSAIDs use history: impact on the genome-wide DNA methylation profile and possible mechanisms of action.Clinical and experimental medicine · 2023Article
- Review
- Article
- The genome-wide DNA methylation profiles among neurosurgery patients with and without post-operative delirium.Psychiatry and clinical neurosciences · 2023Article
- Genome-wide DNA methylation analysis of post-operative delirium with brain, blood, saliva, and buccal samples from neurosurgery patients.Journal of psychiatric research · 2022Article
- The potential benefit of metformin to reduce delirium risk and mortality: a retrospective cohort study.Aging · 2022Article
- DNA methylation in the inflammatory genes after neurosurgery and diagnostic ability of post-operative delirium.Translational psychiatry · 2021Article
- AcuteNeurorehabilitation and neural repair · 2021Article
- The Potential Protective Effect of Mesencephalic Astrocyte-Derived Neurotrophic Factor on Post-Operative Delirium via Inhibiting Inflammation and Microglia Activation.Journal of inflammation research · 2021Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
We previously reported the association between DNA methylation (DNAm) of pro-inflammatory cytokine genes and age. In addition, neurotrophic factors are known to be associated with age and neurocognitive disorders. Therefore, we hypothesized that DNAm of neurotrophic genes change with age, especially in delirium patients. DNAm was analyzed using the Illumina HumanMethylation450 or HumanMethylationEPIC BeadChip Kit in 3 independent cohorts: blood from 383 Grady Trauma Project subjects, brain from 21 neurosurgery patients, and blood from 87 inpatients with and without delirium. Both blood and brain samples showed that most of the DNAm of neurotrophic genes were positively correlated with age. Furthermore, DNAm of neurotrophic genes was more positively correlated with age in delirium cases than in non-delirium controls. These findings support our hypothesis that the neurotrophic genes may be epigenetically modulated with age, and this process may be contributing to the pathophysiology of delirium.
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