ArticleiScience2020
Notch and Delta Control the Switch and Formation of Camouflage Patterns in Caterpillars.
Article in iScience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Ectopic Wnt6 expression induces twin-spot markings in the epidermis of the silkworm Bombyx mori - Potential molecular target to discover evolutionary mechanisms of adaptive body coloration in insects.The FEBS journal · 2026Article
- The pigment transporter Redboy confers programmed body colour transition in orchid mantises.Nature ecology & evolution · 2025Article
- Notch Signaling in Insect Development: A Simple Pathway with Diverse Functions.International journal of molecular sciences · 2023Review
- The genetic basis of wing spots in Pieris canidia butterflies.BMC genomics · 2023Article
- The Ubiquitin Conjugating Enzyme UbcD1 is Required for Notch Signaling Activation DuringFrontiers in genetics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In most Papilio species, a younger larva mimics bird droppings but changes its pattern to match host plant colors in its final instar. This change is determined by juvenile hormone (JH) during the JH-sensitive period (JHSP) early in the fourth instar. Recently, we found that homeobox genes control the pre-pattern formation specifically during JHSP, but the molecular mechanisms underlying final patterning and pigmentation at molt are unknown. By knockdown of Delta and Notch in Papilio xuthus larvae, we here showed that these genes define the edge and pigmentation area in final patterns, during and even after JHSP, suggesting that they bridge the JHSP and molt. Knockdown of Delta in Papilio machaon led to similar phenotypic changes, and knockdown of Notch caused pigmentation loss in twin spots of the silkworm Multilunar (L) mutant. Our findings suggest the importance of the Notch signaling pathway in caterpillars' adaptive evolution of color pattern formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.