Evidence map›Paper›PMID 32649920›Full record

ArticleThe Lancet. Respiratory medicine2020

Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society.

Hiroto Hatabu, Gary M Hunninghake, Luca Richeldi, Kevin K Brown, Athol U Wells, Martine Remy-Jardin, Johny Verschakelen, Andrew G Nicholson, Mary B Beasley, David C Christiani and 12 more

Open access · greenAbstract readConsensus Statement
PubMed Full text at PMC Publisher
In one paragraph

Article in The Lancet. Respiratory medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 342 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
342citing papers in PubMed, 9 pooled it
36.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

342 citing papers in PubMed, 9 syntheses or guidelines pooled it, 544 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. A systematic review of the role of quantitative CT in the prognostication and disease monitoring of interstitial lung disease.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  6. Pooled it
  7. Pooled it
  8. Pooled it
  9. Pooled it
  10. Article
  11. Article
  12. Observational
  13. Review
  14. Cause of death in fibrotic and nonfibrotic interstitial lung abnormalities: the MESA study.American journal of respiratory and critical care medicine · 2026
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article

282 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 16 institutions in 8 countries.

Hiroto HatabuDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. Electronic address: hhatabu@partners.org.
Gary M HunninghakeDepartment of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Luca RicheldiUnitá Operativa Complessa di Pneumologia, Universitá Cattolica del Sacro Cuore, Fondazione Policlinico A Gemelli IRCCS, Rome, Italy.
Kevin K BrownDepartment of Medicine, Denver, CO, USA; National Jewish Health, Denver, CO, USA.
Athol U WellsDepartment of Respiratory Medicine, Royal Brompton and Hospital NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Martine Remy-JardinDepartment of Thoracic Imaging, Hospital Calmette, University Centre of Lille, Lille, France.
Johny VerschakelenDepartment of Radiology, University Hospitals Leuven, Leuven, Belgium.
Andrew G NicholsonDepartment of Histopathology, Royal Brompton and Hospital NHS Foundation Trust, London, UK; National Heart and Lung Institute, Imperial College London, London, UK.
Mary B BeasleyDepartment of Pathology, Icahn School of Medicine at Mount, New York, NY, USA.
David C ChristianiDepartment of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Raúl San José EstéparDepartment of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Joon Beom SeoDepartment of Radiology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Takeshi JohkohDepartment of Radiology, Kansai Rosai Hospital, Hyogo, Japan.
Nicola SverzellatiDepartment of Medicine and Surgery, University of Parma, Parma, Italy.
Christopher J RyersonDepartment of Medicine, University of British Columbia and Centre for Heart Lung Innovations, St Paul's Hospital, Vancouver, BC, Canada.
R Graham BarrDepartment of Medicine and Department of Epidemiology, Columbia University Medical Center, New York, NY, USA.
Jin Mo GooDepartment of Radiology, Seoul National University College of Medicine, Seoul, South Korea.
John H M AustinDepartment of Radiology, Columbia University Medical Center, New York, NY, USA.
Charles A PowellPulmonary, Critical Care and Sleep Medicine, Icahn School of Medicine at Mount, New York, NY, USA.
Kyung Soo LeeDepartment of Radiology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Yoshikazu InoueClinical Research Center, National Hospital Organization Kinki-Chuo Chest Medical Center, Osaka, Japan.
David A LynchDepartment of Radiology, Denver, CO, USA.
Brigham and Women's Hospital · USColumbia University Irving Medical Center · USIcahn School of Medicine at Mount Sinai · USRoyal Brompton Hospital · GBHôpital Albert Calmette · FRIstituti di Ricovero e Cura a Carattere Scientifico · ITKansai Rosai Hospital · JPKU Leuven · BEMassachusetts General Hospital · USNHO Kinki Chuo Chest Medical Center · JPSamsung Medical Center · KRSeoul National University · KRUlsan College · KRUniversity of British Columbia · CAUniversity of Colorado Denver · USUniversity of Parma · IT

Funding

The Boston Lung Cancer Survival CohortU01CA209414 · NCI · HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH · PI David C Christiani · 2017 to 2026
$12.2M
Clinical Genetics and Screening for Pulmonary FibrosisR01HL130974 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI GARY MATTHEW HUNNINGHAKE, Benjamin Alexander Raby · 2016 to 2026
$10.0M
Genetic and Genomic Characterization of the Occurrence and Progression of Interstitial Lung AbnormalitiesR01HL135142 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MICHAEL H. CHO, GARY MATTHEW HUNNINGHAKE · 2017 to 2026
$7.7M
Interstitial Lung Abnormalities: Defining the Phenotype, Causes, and Consequences.R01HL111024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI HUNNINGHAKE, GARY MATTHEW · 2013 to 2022
$6.4M
Molecular and Genetic Analysis of Lung Cancer SurvivalR01CA092824 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 2002 to 2013
$5.9M
LUNG DISEASE IN CHINESE TEXTILE WORKERSR01OH002421 · OH · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1988 to 2020
$5.5M
GENETIC SUSCEPTIBILITY TO LUNG CANCERR01CA074386 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1997 to 2008
$4.8M
The Cardiopulmonary Effects of Particulate ExposureR01ES009860 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI CHRISTIANI, DAVID C · 1999 to 2014
$4.0M
Automated in vivo analysis of tumor growth rate as a guide for therapeutic decisions to advance personalized cancer treatmentR01CA203636 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI NISHINO, MIZUKI · 2017 to 2021
$2.9M
Dynamic contrast-enhanced MRI of pulmonary nodule at 3TR21CA116271 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI HATABU, HIROTO · 2006 to 2007
$358k
NCI NIH HHS R01 CA074386NCI NIH HHS R01 CA092824NCI NIH HHS R01 CA203636NCI NIH HHS R21 CA116271NCI NIH HHS U01 CA209414NHLBI NIH HHS R01 HL111024NHLBI NIH HHS R01 HL130974NHLBI NIH HHS R01 HL135142NIEHS NIH HHS R01 ES009860NIOSH CDC HHS R01 OH002421
6 · The paper itself

Abstract

The term interstitial lung abnormalities refers to specific CT findings that are potentially compatible with interstitial lung disease in patients without clinical suspicion of the disease. Interstitial lung abnormalities are increasingly recognised as a common feature on CT of the lung in older individuals, occurring in 4-9% of smokers and 2-7% of non-smokers. Identification of interstitial lung abnormalities will increase with implementation of lung cancer screening, along with increased use of CT for other diagnostic purposes. These abnormalities are associated with radiological progression, increased mortality, and the risk of complications from medical interventions, such as chemotherapy and surgery. Management requires distinguishing interstitial lung abnormalities that represent clinically significant interstitial lung disease from those that are subclinical. In particular, it is important to identify the subpleural fibrotic subtype, which is more likely to progress and to be associated with mortality. This multidisciplinary Position Paper by the Fleischner Society addresses important issues regarding interstitial lung abnormalities, including standardisation of the definition and terminology; predisposing risk factors; clinical outcomes; options for initial evaluation, monitoring, and management; the role of quantitative evaluation; and future research needs.

Indexed as

Early Detection of CancerIncidental FindingsTomography, X-Ray ComputedHumansLung Diseases, InterstitialLung Neoplasms

Identifiers

PMID32649920
PMCPMC7970441
OpenAlexW3039168731

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.