Evidence map›Paper›PMID 32649909›Full record

ArticleCurrent biology : CB2020

Tendon Cell Regeneration Is Mediated by Attachment Site-Resident Progenitors and BMP Signaling.

Xubo Niu, Arul Subramanian, Tyler H Hwang, Thomas F Schilling, Jenna L Galloway

Open access · bronzeAbstract read
In one paragraph

Article in Current biology : CB, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
3.5field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  7. Interfacial Tissue Regeneration with Bone.Current osteoporosis reports · 2024
    Review
  8. Article
  9. Article
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  13. Review
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  15. The impact of Drew Noden's work on our understanding of craniofacial musculoskeletal integration.Developmental dynamics : an official publication of the American Association of Anatomists · 2022
    Review
  16. Growth and mechanobiology of the tendon-bone enthesis.Seminars in cell & developmental biology · 2022
    Review
  17. Comparison of Tendon Development Versus Tendon Healing and Regeneration.Frontiers in cell and developmental biology · 2022
    Review
  18. Bringing tendon biology to heel: Leveraging mechanisms of tendon development, healing, and regeneration to advance therapeutic strategies.Developmental dynamics : an official publication of the American Association of Anatomists · 2021
    Review
  19. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Xubo NiuCenter for Regenerative Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Arul SubramanianDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Tyler H HwangCenter for Regenerative Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA.
Thomas F SchillingDepartment of Developmental and Cell Biology, University of California, Irvine, Irvine, CA 92697, USA.
Jenna L GallowayCenter for Regenerative Medicine, Department of Orthopaedic Surgery, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA. Electronic address: jenna_galloway@hms.harvard.edu.
Harvard University · USUniversity of California, Irvine · US

Funding

THE ROLE OF ATROPHIN-2 IN CARTILAGE PATTERNING AND POLARITY IN ZEBRAFISHR01DE013828 · NIDCR · UNIVERSITY OF CALIFORNIA-IRVINE · PI SCHILLING, THOMAS F · 2001 to 2025
$9.1M
Regulation of Morphogenesis and Extracellular Matrix Assembly at the Myotendinous JunctionR01AR067797 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI Thomas F Schilling · 2016 to 2026
$3.5M
Multiscale Models of Wound Cell Plasticity for RegenerationU01AR073159 · NIAMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI DAI, XING, NIE, QING · 2018 to 2022
$3.5M
Defining an Integrated Signaling Network That Patterns the Craniofacial SkeletonR01DE023050 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI CLOUTHIER, DAVID E., NIE, QING · 2014 to 2018
$3.2M
Mechanisms underlying tendon regeneration and attachment site pattern restorationR01AR074541 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI GALLOWAY, JENNA L · 2019 to 2023
$1.8M
Genetic and chemical screening in zebrafish to study tendon developmentR00HD069533 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI GALLOWAY, JENNA L · 2013 to 2015
$677k
Identifying gene and regulatory networks underlying postnatal tendon cell growthR21AR071554 · NIAMS · MASSACHUSETTS GENERAL HOSPITAL · PI CAPELLINI, TERENCE D, GALLOWAY, JENNA L · 2017 to 2018
$405k
The origin and function of tendon progenitors in craniofacial morphogenesis and patterningR03DE024771 · NIDCR · MASSACHUSETTS GENERAL HOSPITAL · PI GALLOWAY, JENNA L · 2015 to 2016
$261k
Genetic and chemical screening in zebrafish to study tendon developmentK99HD069533 · NICHD · HARVARD MEDICAL SCHOOL · PI GALLOWAY, JENNA L · 2011 to 2012
$178k
NIAMS NIH HHS R01 AR067797NIAMS NIH HHS R01 AR074541NIAMS NIH HHS R21 AR071554NIAMS NIH HHS U01 AR073159NICHD NIH HHS K99 HD069533NICHD NIH HHS R00 HD069533NIDCR NIH HHS R01 DE013828NIDCR NIH HHS R01 DE023050NIDCR NIH HHS R03 DE024771
6 · The paper itself

Abstract

The musculoskeletal system is a striking example of how cell identity and position is coordinated across multiple tissues to ensure function. However, it is unclear upon tissue loss, such as complete loss of cells of a central musculoskeletal connecting tendon, whether neighboring tissues harbor progenitors capable of mediating regeneration. Here, using a zebrafish model, we genetically ablate all embryonic tendon cells and find complete regeneration of tendon structure and pattern. We identify two regenerative progenitor populations, sox10

Indexed as

RegenerationAnimalsAnimals, Genetically ModifiedBone Morphogenetic ProteinsCell DifferentiationMusculoskeletal SystemStem CellsTendonsZebrafishBone Morphogenetic ProteinsablationBMPnkx2.5progenitor cellsregenerationscleraxissox10tendonzebrafish

Identifiers

PMID32649909
PMCPMC7484193
OpenAlexW3042010770

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.