Evidence map›Paper›PMID 32649903›Full record

ArticleStem cell reports2020

Arachidonic Acid Promotes Intestinal Regeneration by Activating WNT Signaling.

Qingyu Wang, Yingying Lin, Xiaole Sheng, Jiuzhi Xu, Xuening Hou, Yuan Li, Hao Zhang, Huiyuan Guo, Zhengquan Yu, Fazheng Ren

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 65 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qingyu WangKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Yingying LinKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Xiaole ShengState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Jiuzhi XuState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Xuening HouState Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Yuan LiKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Hao ZhangKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Huiyuan GuoKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China.
Zhengquan YuKey Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China; State Key Laboratories for Agrobiotechnology, College of Biological Sciences, China Agricultural University, Beijing, China.
Fazheng RenKey Laboratory of Functional Dairy, Beijing Laboratory of Food Quality and Safety, College of Food Science & Nutritional Engineering, China Agricultural University, Beijing, China; Key Laboratory of Precision Nutrition and Food Quality, Department of Nutrition and Health, China Agricultural University, Beijing, China. Electronic address: renfazheng@cau.edu.cn.
China Agricultural University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intestinal regeneration is crucial for functional restoration after injury, and nutritional molecules can play an important role in this process. Here, we found that arachidonic acid (AA) serves as a direct proliferation promoter of intestinal epithelial cells that facilitates small intestinal regeneration in both three-dimensional cultured organoids and mouse models. As shown in the study, during post-irradiation regeneration, AA positively regulates intestinal epithelial cell proliferation by upregulating the expression of Ascl2 and activating WNT signaling, but negatively regulates intestinal epithelial cell differentiation. AA acts as a delicate regulator that efficiently facilitates epithelial tissue repair by activating radiation-resistant Msi1

Indexed as

Wnt Signaling PathwayAnimalsArachidonic AcidBasic Helix-Loop-Helix ProteinsCell DifferentiationCell LineCell ProliferationEpithelial CellsIntestine, SmallMaleMice, Inbred C57BLOrganoidsRadiation, IonizingRegenerationSpheroids, CellularTranscriptomeArachidonic AcidAscl2 protein, mouseBasic Helix-Loop-Helix Proteinsarachidonic aciddifferentiationfatty acidsintestinal stem cellsirradiation injuryproliferationWNT signaling

Identifiers

PMID32649903
PMCPMC7419670
OpenAlexW3041934953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.