Evidence map›Paper›PMID 32649829›Full record

ArticleAnalytical chemistry2020

Mass Defect-Based DiLeu Tagging for Multiplexed Data-Independent Acquisition.

Xiaofang Zhong, Dustin C Frost, Qinying Yu, Miyang Li, Ting-Jia Gu, Lingjun Li

Open access · greenAbstract read
In one paragraph

Article in Analytical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 24 citations in OpenAlex.

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  6. 6-PlexAnalytical chemistry · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Xiaofang ZhongSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Dustin C FrostSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0002-8239-5274
Qinying YuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Miyang LiDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Ting-Jia GuSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.
Lingjun LiSchool of Pharmacy, University of Wisconsin-Madison, Madison, Wisconsin 53705, United States.ORCID 0000-0003-0056-3869
University of Wisconsin–Madison · US

Funding

Wisconsin Alzheimer's Disease Research CenterP30AG062715 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI Barbara Brigitta Bendlin · 2019 to 2026
$34.5M
Wisconsin Alzheimer's Disease Research CenterP50AG033514 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI SAGER, MARK · 2009 to 2018
$16.2M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Mass Spectrometric Studies of Neuropeptides in FeedingR01DK071801 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI LINGJUN LI · 2006 to 2026
$6.7M
Di-Leu-enabled multiplexed quantitation for biomarker discovery and validation in Alzheimer's diseaseRF1AG052324 · NIA · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2018 to 2018
$2.4M
Acquisition of a High-Field Dual Source FTICR-MS for Pharmaceutical ResearchS10RR029531 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI LI, LINGJUN · 2011 to 2011
$2.1M
NCRR NIH HHS S10 RR029531NIA NIH HHS P30 AG062715NIA NIH HHS P50 AG033514NIA NIH HHS RF1 AG052324NIDDK NIH HHS R01 DK071801NIGMS NIH HHS P41 GM108538
6 · The paper itself

Abstract

The unbiased selection of peptide precursors makes data-independent acquisition (DIA) an advantageous alternative to data-dependent acquisition (DDA) for discovery proteomics, but traditional multiplexed quantification approaches employing mass difference labeling or isobaric tagging are incompatible with DIA. Here, we describe a strategy that permits multiplexed quantification by DIA using mass defect-based

Indexed as

Alzheimer DiseaseAmino Acid SequenceBiomarkersCerebrospinal Fluid ProteinsHumansLeucineMiddle AgedProof of Concept StudyProteomeProteomicsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsTandem Mass SpectrometryBiomarkersCerebrospinal Fluid ProteinsLeucineProteomeSaccharomyces cerevisiae Proteins

Identifiers

PMID32649829
PMCPMC7438256
OpenAlexW3041908969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.