ArticlePloS one2020
A cross-sectional study on the rate of non-adherence to anti-seizure medications and factors associated with non-adherence among patients with epilepsy.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Factors Associated With Antiseizure Medication Adherence in Patients With Epilepsy: A Systematic Review.Brain and behavior · 2026Pooled it
- Pooled it
- Non-adherence to epileptic medications among adult patients in south west Shewa zone hospitals of central Ethiopia.Scientific reports · 2025Article
- Medication self-management in patients with epilepsy: a narrative review of current status, influencing factors, and intervention strategies.Frontiers in neurology · 2025Review
- Development and Validation of a New Adherence Scale for Antiseizure Medications [ASASM].Journal of clinical medicine · 2024Article
- Non-Adherence to Antiseizure Medications: Rate and Predictors in Saudi Arabia.Medicina (Kaunas, Lithuania) · 2024Article
- Adherence to Epilepsy's Medical Recommendations.Brain sciences · 2024Article
- Association of antiseizure medication adherence with illness perceptions in adults with epilepsy.Epilepsy & behavior : E&B · 2023Article
- Exercise, medication adherence, and the menstrual cycle: How much do these change seizure risk?Epilepsy research · 2022Review
- Detecting Reasons for Nonadherence to Medication in Adults with Epilepsy: A Review of Self-Report Measures and Key Predictors.Journal of clinical medicine · 2022Review
- Current Principles in the Management of Drug-Resistant Epilepsy.CNS drugs · 2022Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNon-adherence to anti-seizure medication (ASM) therapy is an important contributing factor to the higher mortality rate and treatment failure of epilepsy. This study aimed to determine the rate and factors associated with non-adherence to ASM therapy through the WHO five dimensions of medication adherence framework.
methodsWe conducted a cross-sectional study at an outpatient Neurology Clinic of a tertiary government hospital in Malaysia. Between March and July 2019, we identified 217 patients with a confirmed diagnosis of epilepsy, receiving oral ASM therapy and able to administer their medications. We performed a semi-structured interview to gather information on sociodemographic background, clinical and medication history, and perceptions on healthcare services. Adherence to ASM therapy was evaluated using the Medication Compliance Questionnaire (MCQ). Patient's illness perception was assessed by the Brief Illness Perception Questionnaire (B-IPQ).
results208 patients participated in this study. The median age of the study participants was 35 years (IQR 26-44). 58.2% were females and majority, 55.8%, were from the Malay ethnic group. Based on the MCQ scoring, 89 patients (42.8%) were non-adherent. Multiple logistic regression demonstrated that being employed or students (adjusted odds ratio [aOR] 2.26, 95%CI: 1.19-4.29 p = 0.012) and having an average or below average perceived access to pharmacy services (aOR 2.94, 95%CI: 1.38-6.24, p = 0.005) were significant contributors to non-adherence.
conclusionBeing employed or students and having an average or below average perceived access to pharmacy services were associated with ASM non-adherence Efforts to improve ASM adherence should adopt a comprehensive approach considering the success of adherence is contingent on the interrelationship of multiple dimensions.
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