ArticlePloS one2020
Analysis of the fetal cardio-electrohysterographic coupling at the third trimester of gestation in healthy women by Bivariate Phase-Rectified Signal Averaging.
Article in PloS one, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Non-linear Methods Predominant in Fetal Heart Rate Analysis: A Systematic Review.Frontiers in medicine · 2021Pooled it
- Higher body-mass index modifies time-resolved maternal autonomic cardiac-uterine coupling during the first stage of human labour.Experimental physiology · 2026Article
- Transformer-based deep learning for estimating bidirectional maternal-fetal cardiac coupling.Frontiers in medical technology · 2026Article
- Cardiorespiratory mechanisms triggered during music perception in preterm infants and adults.iScience · 2025Article
- Maternal cardiorespiratory coupling: differences between pregnant and nonpregnant women are further amplified by sleep-stage stratification.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Deep learning identifies cardiac coupling between mother and fetus during gestation.Frontiers in cardiovascular medicine · 2022Article
- The Reconstruction of Causal Networks in Physiology.Frontiers in network physiology · 2022Article
- Multiparametric Investigation of Dynamics in Fetal Heart Rate Signals.Bioengineering (Basel, Switzerland) · 2021Article
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7 authors.
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Abstract
introductionThe fetal cardio-electrohysterographic coupling (FCEC) is defined as the influence of the uterine electrical activity on fetal heart rate. FCEC has been mainly evaluated by visual analysis of cardiotocographic data during labor; however, this physiological phenomenon is poorly explored during the antenatal period. Here we propose an approach known as Bivariate Phase-Rectified Signal Averaging analysis (BPRSA) to assess such FCEC in the late third trimester of low-risk pregnancies. We hypothesized that BPRSA is a more reliable measure of FCEC than visual analysis and conventional measures such as cross-correlation, coherence, and cross-sample entropy. Additionally, by using BPRSA it is possible to detect FCEC even from the third trimester of pregnancy. MATERIAL AND
methodsHealthy pregnant women in the last third trimester of pregnancy (36.6 ± 1.8 gestational weeks) without any clinical manifestation of labor were enrolled in the Maternal and Childhood Research Center (CIMIGen), Mexico City (n = 37). Ten minutes of maternal electrohysterogram (EHG) and fetal heart rate (FHR) data were collected by a transabdominal non-invasive device. The FCEC was quantified by the coefficient of coherence, the maximum normalized cross-correlation, and the cross-sample entropy obtained either from the EHG and FHR raw signals or from the corresponding BPRSA graphs.
resultsWe found that by using BPRSA, the FCEC was detected in 92% cases (34/37) compared to 48% cases (18/37) using the coefficient of coherence between the EHG and FHR raw signals. Also, BPRSA indicated FCEC in 82% cases (30/37) compared to 30% cases (11/37) using the maximum normalized cross-correlation. By comparing the analyses, the BPRSA evidenced higher FCEC in comparison to the coupling estimated from the raw EHG and FHR signals.
conclusionsOur results support the consideration that in the third trimester of pregnancy, the fetal heart rate is also influenced by uterine activity despite the emerging manifestation of this activity before labor. To quantify FCEC, the BPRSA can be applied to FHR and EHG transabdominal signals acquired in the third trimester of pregnancy.
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