ArticlePLoS computational biology2020
The interplay between somatic and dendritic inhibition promotes the emergence and stabilization of place fields.
Article in PLoS computational biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 28 citations in OpenAlex.
- Homeostatic Plasticity Enables Stable yet Tunable Neuronal Assemblies.bioRxiv : the preprint server for biology · 2026Article
- Behavioral Timescale Synaptic Plasticity: A Burst in the Field of Learning and Memory.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Hippocampal OLM interneurons regulate CA1 place cell plasticity and remapping.Nature communications · 2025Article
- The estrous cycle modulates hippocampal spine dynamics, dendritic processing, and spatial coding.Neuron · 2025Article
- Untangling stability and gain modulation in cortical circuits with multiple interneuron classes.eLife · 2025Article
- Synaptic plasticity rules driving representational shifting in the hippocampus.Nature neuroscience · 2025Article
- The Structure of Hippocampal CA1 Interactions Optimizes Spatial Coding across Experience.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Endogenous Modulators of NMDA Receptor Control Dendritic Field Expansion of Cortical Neurons.Molecular neurobiology · 2023Article
- Assessing Local and Branch-specific Activity in Dendrites.Neuroscience · 2022Article
- Dendritic Excitability and Synaptic Plasticity In Vitro and In Vivo.Neuroscience · 2022Review
- Local feedback inhibition tightly controls rapid formation of hippocampal place fields.Neuron · 2022Article
- Dendritic normalisation improves learning in sparsely connected artificial neural networks.PLoS computational biology · 2021Article
- Distinct place cell dynamics in CA1 and CA3 encode experience in new environments.Nature communications · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
During the exploration of novel environments, place fields are rapidly formed in hippocampal CA1 neurons. Place cell firing rate increases in early stages of exploration of novel environments but returns to baseline levels in familiar environments. Although similar in amplitude and width, place fields in familiar environments are more stable than in novel environments. We propose a computational model of the hippocampal CA1 network, which describes the formation, dynamics and stabilization of place fields. We show that although somatic disinhibition is sufficient to form place fields, dendritic inhibition along with synaptic plasticity is necessary for place field stabilization. Our model suggests that place cell stability can be attributed to strong excitatory synaptic weights and strong dendritic inhibition. We show that the interplay between somatic and dendritic inhibition balances the increased excitatory weights, such that place cells return to their baseline firing rate after exploration. Our model suggests that different types of interneurons are essential to unravel the mechanisms underlying place field plasticity. Finally, we predict that artificially induced dendritic events can shift place fields even after place field stabilization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.