ArticleThe Journal of cardiovascular nursing
Factors Associated With Cognitive Impairment in Heart Failure With Preserved Ejection Fraction.
Article in The Journal of cardiovascular nursing. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Brain Imaging Changes and Related Risk Factors of Cognitive Impairment in Patients With Heart Failure.Frontiers in cardiovascular medicine · 2021Pooled it
- Exploring the Relationship Between Sleep Disturbances, Gut Microbiota, and Cognition in Patients with Heart Failure: A Cross-Sectional Study.Medicina (Kaunas, Lithuania) · 2026Article
- Prevalence and Latent Profiles of Cognitive Impairment in Patients with Heart Failure: A Secondary Data Analysis.Journal of clinical medicine · 2026Article
- Parental obesity exacerbates cognitive dysfunction and cardiac vulnerability in offspring of an Alzheimer disease model.American journal of physiology. Heart and circulatory physiology · 2026Article
- Assessment of cognitive function in patients with heart failure: impact of clinical and sociodemographic factors.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Relationship between cardiac index and brain volume in the UK Biobank.Cerebral circulation - cognition and behavior · 2026Article
- Predicting Cognitive Impairment in Elderly Patients with HFpEF: Development of a Simple Clinical Risk Score.Journal of clinical medicine · 2025Article
- Review
- Review
- Trajectory of Cognitive Decline After Incident Heart Failure Hospitalization: Findings From the REGARDS Study.Journal of the American Heart Association · 2024Article
- Heart failure with preserved ejection fraction.Nature reviews. Disease primers · 2024Review
- Association of cardiovascular diseases with cognitive performance in older adults.American heart journal · 2024Article
- Heart-brain interaction in cardiogenic dementia: pathophysiology and therapeutic potential.Frontiers in cardiovascular medicine · 2024Review
- Review
- Cognitive Dysfunction in Heart Failure: Pathophysiology and Implications for Patient Management.Current heart failure reports · 2022Review
- Cognitive Impairment in Heart Failure: Landscape, Challenges, and Future Directions.Frontiers in cardiovascular medicine · 2021Review
- Impact and Implications of Neurocognitive Dysfunction in the Management of Ischemic Heart Failure.Journal of the Society for Cardiovascular Angiography & InterventionsReview
- Atrial Fibrillation and Older Age Predict Serum Brain-Derived Neurotrophic Factor Levels Among Patients With Heart Failure.The Journal of cardiovascular nursingArticle
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundCognitive impairment is prevalent in heart failure and is associated with higher mortality rates. The mechanism behind cognitive impairment in heart failure with preserved ejection fraction (HFpEF) has not been established.
objectiveThe aim of this study was to evaluate associations between abnormal cardiac hemodynamics and cognitive impairment in individuals with HFpEF.
methodsA secondary analysis of Atherosclerosis Risk in Communities (Atherosclerosis Risk in Communities) study data was performed. Participants free of stroke or dementia who completed in-person assessments at visit 5 were included. Neurocognitive test scores among participants with HFpEF, heart failure with reduced ejection fraction (HFrEF), and no heart failure were compared. Sociodemographics, comorbid illnesses, medications, and echocardiographic measures of cardiac function that demonstrated significant (P < .10) bivariate associations with neurocognitive test scores were included in multivariate models to identify predictors of neurocognitive test scores among those with HFpEF. Multiple imputation by chained equations was used to account for missing values.
resultsScores on tests of attention, language, executive function, and global cognitive function were worse among individuals with HFpEF than those with no heart failure. Neurocognitive test scores were not significantly different among participants with HFpEF and HFrEF. Worse diastolic function was weakly associated with worse performance in memory, attention, and language. Higher cardiac index was associated with worse performance on 1 test of attention.
conclusionsCognitive impairment is prevalent in HFpEF and affects several cognitive domains. The current study supports the importance of cognitive screening in patients with heart failure. An association between abnormal cardiac hemodynamics and cognitive impairment was observed, but other factors are likely involved.
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