Evidence map›Paper›PMID 32649034›Full record

ArticleAddiction (Abingdon, England)2021

Association between marijuana use and electrocardiographic abnormalities by middle age: the Coronary Artery Risk Development in Young Adults (CARDIA) study.

Julian Jakob, Odile Stalder, Lamprini Syrogiannouli, Mark J Pletcher, Eric Vittinghoff, Hongyan Ning, Kali Tal, Jamal S Rana, Stephen Sidney, Donald M Lloyd-Jones and 1 more

Abstract read
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In one paragraph

Article in Addiction (Abingdon, England), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Julian JakobInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.ORCID 0000-0001-8429-3231
Odile StalderClinical Trials Unit (CTU) Bern, University of Bern, Bern, Switzerland.ORCID 0000-0002-5563-2975
Lamprini SyrogiannouliInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.
Mark J PletcherDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0002-6966-1312
Eric VittinghoffDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.ORCID 0000-0001-8535-0920
Hongyan NingNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.
Kali TalInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.ORCID 0000-0003-2454-2560
Jamal S RanaDepartment of Cardiology, Kaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0002-8222-3958
Stephen SidneyKaiser Permanente Northern California, Oakland, CA, USA.ORCID 0000-0001-7454-5036
Donald M Lloyd-JonesNorthwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-0847-6110
Reto AuerInstitute of Primary Health Care (BIHAM), University of Bern, Bern, Switzerland.ORCID 0000-0003-4222-4849

Funding

NHLBI NIH HHS HHSN268201800003INHLBI NIH HHS HHSN268201800004INHLBI NIH HHS HHSN268201800005INHLBI NIH HHS HHSN268201800006INHLBI NIH HHS HHSN268201800007I
6 · The paper itself

Abstract

aimsTo evaluate the prevalence of electrocardiogram (ECG) abnormalities in marijuana users as an indirect measure of subclinical cardiovascular disease (CVD).

designLongitudinal and cross-sectional secondary data analysis from the CARDIA (Coronary Artery Risk Development in Young Adults) study.

settingFour communities in the United States.

participantsA total of 2585 participants from the 5115 black and white men and women recruited at age 18-30 years in 1985 to 1986 in CARDIA. MEASUREMENTS: ECG abnormalities coded as minor and major abnormalities with the Minnesota code of electrocardiographic findings at year 20. Self-reported current (past 30 days) and computed cumulative life-time marijuana use (one 'marijuana-year' corresponds to 365 days of use) through assessments every 2-5 years. We fitted logistic regression models adjusting for sex, race, center, education, age, tobacco smoking, physical activity, alcohol use and body mass index.

findingsAmong the 2585 participants with an ECG at year 20, mean age was 46, 57% were women, 45% were black; 83% had past exposure to marijuana and 11% were using marijuana currently. One hundred and seventy-three participants (7%) had major abnormalities and 944 (37%) had minor abnormalities. Comparing current with never use in multivariable-adjusted models, the odds ratio (OR) for major ECG abnormalities was 0.60 [95% confidence interval (CI) = 0.32-1.15] and for minor ECG abnormalities 1.21 (95% CI = 0.87-1.68). Results did not change after stratifying by sex and race. Cumulative marijuana use was not associated with ECG abnormalities.

conclusionIn a middle-aged US population, life-time cumulative and occasional current marijuana use were not associated with increases in electrocardiogram abnormalities. This adds to the growing body of evidence that occasional marijuana use and cardiovascular disease events and markers of subclinical atherosclerosis are not associated.

Indexed as

Cardiovascular DiseasesMarijuana SmokingMarijuana UseAdolescentAdultCoronary VesselsCross-Sectional StudiesElectrocardiographyFemaleHumansMaleMiddle AgedRisk FactorsUnited StatesYoung AdultCARDIAcohort studyECGepidemiologymarijuanasubclinical CVD

Identifiers

PMID32649034
PMCPMC7796923

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.