Evidence map›Paper›PMID 32648973›Full record

ReviewJournal of medical virology2021

Extrapulmonary complications of COVID-19: A multisystem disease?

Kenneth I Zheng, Gong Feng, Wen-Yue Liu, Giovanni Targher, Christopher D Byrne, Ming-Hua Zheng

Abstract readReview
In one paragraph

Review in Journal of medical virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Article
  7. The effects of SARS-CoV-2 on bone homeostasis.Frontiers in endocrinology · 2026
    Review
  8. Article
  9. New mouse model for inducible hACE2 expression enables to dissect SARS-CoV-2 pathology beyond the respiratory system.Mammalian genome : official journal of the International Mammalian Genome Society · 2025
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39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kenneth I ZhengMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0002-1726-9298
Gong FengXi'an Medical University, Xi'an, China.
Wen-Yue LiuDepartment of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Giovanni TargherSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, Italy.ORCID 0000-0002-4325-3900
Christopher D ByrneSouthampton National Institute for Health Research Biomedical Research Center, Southampton General Hospital, University Hospital Southampton, Southampton, UK.ORCID 0000-0001-6322-7753
Ming-Hua ZhengMAFLD Research Center, Department of Hepatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.ORCID 0000-0003-4984-2631

Funding

National Natural Science Foundation of China 81500665Southampton NIHR Biomedical Research Centre IS-BRC-20004
6 · The paper itself

Abstract

The outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been recently declared a pandemic by the World Health Organization. In addition to its acute respiratory manifestations, SARS-CoV-2 may also adversely affect other organ systems. To date, however, there is a very limited understanding of the extent and management of COVID-19-related conditions outside of the pulmonary system. This narrative review provides an overview of the current literature about the extrapulmonary manifestations of COVID-19 that may affect the urinary, cardiovascular, gastrointestinal, hematological, hematopoietic, neurological, or reproductive systems. This review also describes the current understanding of the extrapulmonary complications caused by COVID-19 to improve the management and prognosis of patients with COVID-19.

Indexed as

Cardiovascular InfectionsCOVID-19Gastrointestinal DiseasesHematologic DiseasesHumansNervous System DiseasesReproductive Tract InfectionsUrologic DiseasesCOVID-19extrapulmonary manifestationsmanagementSARS-CoV-2

Identifiers

PMID32648973
PMCPMC7405144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.