ArticleAllergy2021
Estrogen receptor-α signaling increases allergen-induced IL-33 release and airway inflammation.
Article in Allergy, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 1 synthesis or guideline pooled it, 75 citations in OpenAlex.
- Effects of Sex and Gender in Immediate β-Lactam Antibiotic Allergy: A Systematic Review and Meta-Analysis.The journal of allergy and clinical immunology. In practice · 2025Pooled it
- Activation of lung megakaryocyte α7 nAChR exacerbates allergic airway inflammation via IL-33/p38 MAPK signaling.JCI insight · 2026Article
- An Estrogen-IL-33 Circuit in Aortic Fibroblasts Underlies Sex Differences in Tregs in Abdominal Aortic Aneurysm.JACC. Basic to translational science · 2026Article
- Deficiency in circulating T cells in four core genotypes mice with Sry translocation.Journal of immunology (Baltimore, Md. : 1950) · 2026Article
- Group 2 innate lymphoid cells: Where are we 15 years out?The Journal of allergy and clinical immunology · 2026Review
- Sexual Dimorphism in Allergic and Mast Cell-Associated Diseases.Clinical reviews in allergy & immunology · 2026Review
- Ovarian hormones and obesity drive Th17-mediated airway inflammation through estrogen receptor-α signaling.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Sex chromosomes and gonadal sex interactions in airway and immune responses to allergen challenge.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Sex Differences in Lung Immunity.Immunological reviews · 2026Review
- Exploring the toxicological effects of Di-O-benzoyldiethylene glycol plasticizer on allergic rhinitis through network toxicology combined with molecular docking and molecular simulation.Scientific reports · 2026Article
- Sex differences in immune modulation: implications for infection, inflammation, and nutritional supplementation.Biology of sex differences · 2026Review
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- Crocin protects against smoke-induced chronic obstructive pulmonary disease by regulating AKT1.Frontiers in pharmacology · 2026Article
- Sex differences in immune cells: mechanistic perspectives and clinical correlates in physiology and disease.Frontiers in immunology · 2026Review
- The Relationship of Estrogen Changes With Sinonasal Symptoms and Disease in Women: A Scoping Review.The Laryngoscope · 2025Article
- Oral contraceptives and the risk of asthma attacks: a population-based cohort study.ERJ open research · 2025Article
- NADPH oxidases: redox regulation of cell homeostasis and disease.Physiological reviews · 2025Review
- Effectiveness of dupilumab treatment against refractory eosinophilic chronic rhinosinusitis.The journal of allergy and clinical immunology. Global · 2025Article
- Sex-Specific Immune Responses Mediate Host Specificity in Hookworm Infections.Tropical medicine and infectious disease · 2025Article
- Uncovering the mechanisms of diosmin in treating obesity-related kidney injury based on network pharmacology, molecular docking, and in vitro validation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundGroup 2 innate lymphoid cells (ILC2) are stimulated by IL-33 to increase IL-5 and IL-13 production and airway inflammation. While sex hormones regulate airway inflammation, it remained unclear whether estrogen signaling through estrogen receptor-α (ER-α, Esr1) or ER-β (Esr2) increased ILC2-mediated airway inflammation. We hypothesize that estrogen signaling increases allergen-induced IL-33 release, ILC2 cytokine production, and airway inflammation.
methodsFemale Esr1
resultsAlt Ext challenged Esr1
conclusionEstrogen receptor -α signaling increased IL-33 release and ILC2-mediated airway inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.