Evidence map›Paper›PMID 32648610›Full record

ArticleJournal of neuroimaging : official journal of the American Society of Neuroimaging2020

Microembolic Signals Detected by Transcranial Doppler Predict Future Stroke and Poor Outcomes.

Alvin S Das, Robert W Regenhardt, Sarah LaRose, Andrew D Monk, Pedro M Castro, Faheem G Sheriff, Farzaneh A Sorond, Henrikas Vaitkevicius

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuroimaging : official journal of the American Society of Neuroimaging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07172165 (A Multicenter Study to Optimize Microembolic Signal Classification Based on Double--Blind Multiparametric Assessment by Human Experts Using an Universal Graphical Interface [MESOMEGA]), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07172165 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

A Multicenter Study to Optimize Microembolic Signal Classification Based on Double--Blind Multiparametric Assessment by Human Experts Using an Universal Graphical Interface [MESOMEGA]

TypeobservationalSponsorUniversidade do PortoRan2025 to 2026Enrolled850ConditionsMicroemboli, Stroke, Transcranial Doppler UltrasoundArmsExpert double-blind evaluation
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

Alvin S DasDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-2313-977X
Robert W RegenhardtDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0003-2958-3484
Sarah LaRoseDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Andrew D MonkDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Pedro M CastroDepartment of Neurology, Centro Hospital Universitário São João, Faculty of Medicine, University of Porto, Porto, Portugal.
Faheem G SheriffDepartment of Neurosurgery, The University of Texas Health Science Center at Houston, McGovern Medical School, Houston, TX.
Farzaneh A SorondDepartment of Neurology, Northwestern Memorial Hospital, Feinberg School of Medicine, Chicago, IL.
Henrikas VaitkeviciusDepartment of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.
Brigham and Women's Hospital · USHarvard University · USNorthwestern Memorial Hospital · USThe University of Texas Health Science Center · USUniversidade do Porto · PT

Funding

Neuroscience Resident Research ProgramR25NS065743 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI CASH, SYDNEY S, WILLIAMS, ZIV · 2009 to 2023
$11.8M
NINDS NIH HHS R25 NS065743
6 · The paper itself

Abstract

background and purposeAlthough transcranial Doppler detects microembolic signals (MES) in numerous settings, the practical significance of such findings remains unclear.

methodsClinical information from ischemic stroke or transient ischemic attack patients (n = 248) who underwent embolic monitoring from January 2015 to December 2018 was obtained.

resultsMES were found in 15% of studies and ischemic recurrence was seen in 11% of patients (over 7 ± 6 days). Patients with MES had more lacunes than those without MES (1 ± 3 vs. 1 ± 2, P = .016), were more likely to have ischemic recurrence (37% vs. 6%, P < .001), undergo a future revascularization procedure (26% vs. 10%, P = .005), have a longer length of stay (9 vs. 4 days, P = .043), and have worse functional disability at discharge (modified Rankin Scale 3-6, 66% vs. 34%, P < .001). After controlling for several relevant cofactors, patients with MES were more likely to have ischemic recurrence (HR 4.90, 95% CI 2.16-11.09, P < .001), worse functional disability (OR 3.31, 95% CI 1.22-8.99, P = .019), and longer length of stays (β = .202, P < .001).

conclusionsMES may help to risk stratify patients as their presence is associated with ischemic recurrence and worse outcomes.

Indexed as

AgedAged, 80 and overFemaleHumansIntracranial EmbolismIschemic Attack, TransientMaleMiddle AgedPrognosisRecurrenceStrokeUltrasonography, Doppler, Transcranialcerebral emboliNeurosonologyrecurrencestroketranscranial Doppler sonography

Identifiers

PMID32648610
PMCPMC7721963
OpenAlexW3041247459

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.