Evidence map›Paper›PMID 32648602›Full record

ArticleMedical physics2020

Head and neck multi-organ auto-segmentation on CT images aided by synthetic MRI.

Yingzi Liu, Yang Lei, Yabo Fu, Tonghe Wang, Jun Zhou, Xiaojun Jiang, Mark McDonald, Jonathan J Beitler, Walter J Curran, Tian Liu and 1 more

Abstract read
In one paragraph

Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  18. A review of deep learning based methods for medical image multi-organ segmentation.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2021
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4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Yingzi LiuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Yang LeiDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Yabo FuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Tonghe WangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Jun ZhouDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Xiaojun JiangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Mark McDonaldDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Jonathan J BeitlerDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Walter J CurranDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Tian LiuDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.
Xiaofeng YangDepartment of Radiation Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, 30322, USA.

Funding

Multiparametric MRI-guided Prostate HDR Brachytherapy with Focal Tumor BoostR01CA215718 · NCI · EMORY UNIVERSITY · PI YANG, XIAOFENG · 2018 to 2022
$1.8M
NCI NIH HHS R01 CA215718
6 · The paper itself

Abstract

purposeBecause the manual contouring process is labor-intensive and time-consuming, segmentation of organs-at-risk (OARs) is a weak link in radiotherapy treatment planning process. Our goal was to develop a synthetic MR (sMR)-aided dual pyramid network (DPN) for rapid and accurate head and neck multi-organ segmentation in order to expedite the treatment planning process.

methodsForty-five patients' CT, MR, and manual contours pairs were included as our training dataset. Nineteen OARs were target organs to be segmented. The proposed sMR-aided DPN method featured a deep attention strategy to effectively segment multiple organs. The performance of sMR-aided DPN method was evaluated using five metrics, including Dice similarity coefficient (DSC), Hausdorff distance 95% (HD95), mean surface distance (MSD), residual mean square distance (RMSD), and volume difference. Our method was further validated using the 2015 head and neck challenge data.

resultsThe contours generated by the proposed method closely resemble the ground truth manual contours, as evidenced by encouraging quantitative results in terms of DSC using the 2015 head and neck challenge data. Mean DSC values of 0.91 ± 0.02, 0.73 ± 0.11, 0.96 ± 0.01, 0.78 ± 0.09/0.78 ± 0.11, 0.88 ± 0.04/0.88 ± 0.06 and 0.86 ± 0.08/0.85 ± 0.1 were achieved for brain stem, chiasm, mandible, left/right optic nerve, left/right parotid, and left/right submandibular, respectively.

conclusionsWe demonstrated the feasibility of sMR-aided DPN for head and neck multi-organ delineation on CT images. Our method has shown superiority over the other methods on the 2015 head and neck challenge data results. The proposed method could significantly expedite the treatment planning process by rapidly segmenting multiple OARs.

Indexed as

Head and Neck NeoplasmsTomography, X-Ray ComputedHeadHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingOrgans at RiskRadiotherapy Planning, Computer-Assistedhead and neck radiotherapymulti-organ segmentationtreatment planning

Identifiers

PMID32648602
PMCPMC11696540

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.