Evidence map›Paper›PMID 32648379›Full record

ReviewThe world journal of men's health2021

The Use of Testicular Sperm for Intracytoplasmic Sperm Injection in Patients with High Sperm DNA Damage: A Systematic Review.

Rafael F Ambar, Ashok Agarwal, Ahmad Majzoub, Sarah Vij, Nicholas N Tadros, Chak Lam Cho, Neel Parekh, Edson Borges, Sidney Glina

Open access · diamondAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The world journal of men's health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.2field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 5 countries.

Rafael F AmbarAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-3496-2895
Ashok AgarwalAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA. agarwaa@ccf.org.ORCID https://orcid.org/0000-0003-0585-1026
Ahmad MajzoubAmerican Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-7423-6241
Sarah VijDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0001-8282-2339
Nicholas N TadrosDivision of Urology, Southern Illinois University, Springfield, IL, USA.ORCID https://orcid.org/0000-0002-2272-235X
Chak Lam ChoDepartment of Surgery, Union Hospital, Hong Kong.ORCID https://orcid.org/0000-0003-2520-6833
Neel ParekhDepartment of Urology, Cleveland Clinic, Cleveland, OH, USA.ORCID https://orcid.org/0000-0002-6218-9254
Edson BorgesFertility Medical Group, Sapientiae Institute, São Paulo, Brazil.ORCID https://orcid.org/0000-0002-4971-1925
Sidney GlinaDepartment of Urology, Centro Universitario em Saude do ABC, Santo André, Brazil.ORCID https://orcid.org/0000-0002-9053-5046
Cleveland Clinic · USFaculdade de Medicina do ABC · BRFertility Medical Group · BRSouthern Illinois University School of Medicine · USUnion Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The advent of intracytoplasmic sperm injection (ICSI) has changed the human reproduction landscape by overcoming several limitations related to both male and female infertility factors. However, despite the development of new technologies, the live-birth rate with ICSI has not exceeded 30%. In order to improve assisted reproductive technology outcomes, advanced sperm function analysis have gained increased attention and the effects of sperm DNA fragmentation (SDF) on assisted reproduction success are being extensively studied. Utilizing ejaculated sperm with an elevated SDF has been found to result in poor ICSI outcomes. Furthermore, studies have reported that testicular sperm has lower SDF level, when compared to ejaculated sperm. This has led a number of clinicians world-wide to offer testicular sperm retrieval for ICSI in non-azoospermic males with high SDF. This practice has remained controversial due to lack of high quality evidence.

Indexed as

DNA damageDNA fragmentationInfertility, maleSperm retrieval

Identifiers

PMID32648379
PMCPMC8255394
OpenAlexW3037014443

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.