ArticleEMBO reports2020
Lipoic acid rejuvenates aged intestinal stem cells by preventing age-associated endosome reduction.
Article in EMBO reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 43 citations in OpenAlex.
- Aging-related peroxisomal dysregulation disrupts intestinal stem cell differentiation through alterations of very long-chain fatty acid oxidation.PLoS biology · 2025Article
- Lipoic acid functions in Paneth cells to prevent human intestinal stem cell aging.Nature communications · 2025Article
- Age-associated decline of Coenzyme A leads to intestinal stem cells dysfunction via disturbing iron homeostasis.PLoS genetics · 2025Article
- Antistress and Antiaging Potentials of Alpha-Lipoic Acid: Insights from Cell Culture-Based Experiments.Applied biochemistry and biotechnology · 2024Article
- Liquid- and Semisolid-Filled Hard Gelatin Capsules Containing Alpha-Lipoic Acid as a Suitable Dosage Form for Compounding Medicines and Dietary Supplements.Pharmaceutics · 2024Article
- Inter-cell type interactions that control JNK signaling in the Drosophila intestine.Nature communications · 2024Article
- Kaempferol enhances intestinal repair and inhibits the hyperproliferation of aging intestinal stem cells inFrontiers in cell and developmental biology · 2024Article
- Phase separation of BuGZ regulates gut regeneration and aging through interaction with mNature communications · 2023Article
- Sleep loss impairs intestinal stem cell function and gut homeostasis through the modulation of the GABA signalling pathway in Drosophila.Cell proliferation · 2023Article
- Molecular and Therapeutic Insights of Alpha-Lipoic Acid as a Potential Molecule for Disease Prevention.Revista brasileira de farmacognosia : orgao oficial da Sociedade Brasileira de Farmacognosia · 2023Review
- Quercetin Prevents Intestinal Stem Cell Aging via Scavenging ROS and Inhibiting Insulin Signaling inAntioxidants (Basel, Switzerland) · 2022Article
- Review
- Effects of alpha lipoic acid supplementation on serum lipid profile in patients with metabolic syndrome: A randomized, double-blind, placebo-controlled clinical trial.ARYA atherosclerosis · 2022Article
- Auxilin regulates intestinal stem cell proliferation through EGFR.Stem cell reports · 2022Article
- Rab21 in enterocytes participates in intestinal epithelium maintenance.Molecular biology of the cell · 2022Article
- Insect Gut Regeneration.Cold Spring Harbor perspectives in biology · 2022Review
- Aging-related upregulation of the homeobox gene caudal represses intestinal stem cell differentiation in Drosophila.PLoS genetics · 2021Article
- Neuroglian regulates Drosophila intestinal stem cell proliferation through enhanced signaling via the epidermal growth factor receptor.Stem cell reports · 2021Article
- Taurine represses age-associated gut hyperplasia in Drosophila via counteracting endoplasmic reticulum stress.Aging cell · 2021Article
- Antioxidant Effects of Caffeic Acid Lead to Protection ofFrontiers in cell and developmental biology · 2021Article
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8 authors at 2 institutions in 1 country.
Funding
Abstract
The age-associated decline of adult stem cell function is closely related to the decline in tissue function and age-related diseases. However, the underlying mechanisms that ultimately lead to the observed functional decline of stem cells still remain largely unexplored. This study investigated Drosophila midguts and found a continuous downregulation of lipoic acid synthase, which encodes the key enzyme for the endogenous synthesis of alpha-lipoic acid (ALA), upon aging. Importantly, orally administration of ALA significantly reversed the age-associated hyperproliferation of intestinal stem cells (ISCs) and the observed decline of intestinal function, thus extending the lifespan of Drosophila. This study reports that ALA reverses age-associated ISC dysfunction by promoting the activation of the endocytosis-autophagy network, which decreases in aged ISCs. Moreover, this study suggests that ALA may be used as a safe and effective anti-aging compound for the treatment of ISC-dysfunction-related diseases and for the promotion of healthy aging in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.