ArticleSleep & breathing = Schlaf & Atmung2021
Vitamin D deficiency in patients evaluated for obstructive sleep apnea: is it associated with disease severity?
Article in Sleep & breathing = Schlaf & Atmung, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 4 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 4 syntheses or guidelines pooled it, 20 citations in OpenAlex.
- Serum 25(OH)D levels and obstructive sleep apnea syndrome severity in patients without comorbidities: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2024Pooled it
- Obstructive sleep apnea and vitamin D: an updated systematic review and meta-analysis.Hormones (Athens, Greece) · 2023Pooled it
- Severe Vitamin D Deficiency-A Possible Cause of Resistance to Treatment in Psychiatric Pathology.Medicina (Kaunas, Lithuania) · 2023Pooled it
- The association between serum vitamin D and obstructive sleep apnea: an updated meta-analysis.Respiratory research · 2020Pooled it
- Vitamin D Deficiency Is Associated with a Higher 5-Year Risk of Obstructive Sleep Apnea and CPAP Use in Older Adults: An Anchor-Based Network Meta-Analysis.Medicina (Kaunas, Lithuania) · 2026Article
- Predictors of vitamin D deficiency and quality of life in obese patients with obstructive sleep apnea.Scientific reports · 2026Article
- Effect of CPAP therapy on vitamin D status in patients with obstructive sleep apnea and chronic obstructive pulmonary disease overlap syndrome.Sleep & breathing = Schlaf & Atmung · 2025Article
- Vitamin D deficiency and subsequent risk of obstructive sleep apnea: a multi-institutional retrospective study.Frontiers in nutrition · 2025Article
- Role of vitamin D in the association between pre-stroke sleep quality and poststroke depression and anxiety.Sleep & breathing = Schlaf & Atmung · 2024Article
- Polymorphisms in LRP2 and CUBN genes and their association with serum vitamin D levels and sleep apnea.Sleep & breathing = Schlaf & Atmung · 2024Article
- Obstructive sleep apnea and vitamin D level: Has the dust settled?The clinical respiratory journal · 2024Review
- Associations between Vitamin D Status and Polysomnographic Parameters in Adults with Obstructive Sleep Apnea.Life (Basel, Switzerland) · 2024Article
- Vitamin D Levels in Patients with Overlap Syndrome, Is It Associated with Disease Severity?Journal of personalized medicine · 2022Article
- Pre-operative micronutrient deficiencies in patients with severe obesity candidates for bariatric surgery.Journal of endocrinological investigation · 2021Article
- Excessive daytime sleepiness in sleep apnea: any role of testosterone or vitamin D?Physiological research · 2020Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe aim of the present study was to assess vitamin D levels in a large cohort of OSA patients and to investigate possible correlations with clinical and polysomnographic parameters.
methodsIn this cross-sectional study, 685 consecutive patients underwent type 1 polysomnography (PSG) for OSA diagnosis. They were grouped according to apnea-hypopnea index (AHI) as mild, moderate, and severe. Patients with AHI < 5 served as controls. Demographic, PSG data, and serum levels of vitamin D were measured and compared between groups.
resultsOSA was diagnosed in 617 of the patients (90%). Of those, 94 (15%) had mild OSA, 150 (24%) moderate OSA, and 373 (61%) severe OSA. The risk of vitamin D deficiency (< 20 ng/mL) was observed in 38% of the cohort. OSA patients had lower vitamin D levels compared to controls (23 ng/mL vs 26 ng/mL, p = 0.006). The lowest levels of vitamin D [mean 21] (p < 0.001 among all groups) and the higher prevalence for vitamin D deficiency (45%) were observed in severe OSA patients. After multiparametric adjustments for age, gender, obesity, and comorbidities, severe OSA showed significant independent associations with the risk of vitamin D deficiency [OR (95% CI) 2.002 (1.049-3.819), p = 0.035].
conclusionsA large proportion of patients referred for OSA evaluation had vitamin D deficiency, which was independently associated with severe OSA. However, further research is needed in order to determine the role of vitamin D in OSA patients.
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