ArticleJournal of fluorescence2020
Anticancer Activity Study and Density Functional/Time-Dependent Density Functional Theory (DFT/TD-DFT) Calculations of 2(3),9(10),16(17),23(24)-Tetrakis-(6-Methylpyridin-2-Yloxy)Phthalocyaninato Zn(II).
Article in Journal of fluorescence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 4 citations in OpenAlex.
- Zinc Complexes with Nitrogen Donor Ligands as Anticancer Agents.Molecules (Basel, Switzerland) · 2020Review
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Photodynamic therapy (PDT) is one of the major therapeutic methods for the treatment of infectious diseases and cancer. Recently, cell culture has been used to determine the effect of a given substance on various pathological conditions, such as cancer. In this study, we aimed to investigate the effect of a Zn- phthalocyanine (ZnPc) derivative on selected cancer cells via a cell culture medium. Methylthiazole tetrazolium (MTT) assay was applied to evaluate the cytotoxic activity of 2(3),9(10),16(17),23(24)-tetrakis-(6-methylpyridin-2-yloxy)phthalocyaninato Zn(II) on rat glioma cells (C6 glioma), human lung cancer cells (H1299) and human umbilical vein endothelial cells (HUVEC). The levels of the lipid peroxidation were determined by measuring the amount of the thiobarbituric acid reactive substance (TBARS) produced using the TBARS assay. The relationship between the oxidative damage and the effective concentration of cytotoxic ZnPc was determined from the results. The apoptotic and genotoxic effects of the phthalocyanine (Pc) were also investigated. Density functional/time-dependent density functional theory (DFT/TD-DFT) methods were used to determine the molecular excited state properties of the ZnPc and chloroaluminum phthalocyanine (ClAlPc) previously reported by Castilho-Fernandes et al. The computed and experimental data were used to establish a link between the electronic and anticancer properties of the Pcs.
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Registered trials
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