Evidence map›Paper›PMID 32648073›Full record

ArticleJapanese journal of ophthalmology2020

Factors associated with macular vessel density measured by optical coherence tomography angiography in healthy and glaucomatous eyes.

Kwanghyun Lee, Chan Keum Park, Eun Woo Kim, Joo Yeon Kim, Heon Yang, Wungrak Choi, Sang Yeop Lee, Gong Je Seong, Chan Yun Kim, Hyoung Won Bae

Abstract read
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In one paragraph

Article in Japanese journal of ophthalmology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kwanghyun LeeDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Chan Keum ParkDepartment of Ophthalmology, Maryknoll Hospital, Busan, South Korea.
Eun Woo KimDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Joo Yeon KimDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Heon YangDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Wungrak ChoiDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Sang Yeop LeeDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Gong Je SeongDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Chan Yun KimDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea.
Hyoung Won BaeDepartment of Ophthalmology, The Institute of Vision Research, Yonsei University College of Medicine, 50-1, Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. BAEKWON@yuhs.ac.

Funding

Ministry of Education NRF-2019R1F1A1061795
6 · The paper itself

Abstract

purposeTo investigate factors associated with macular vessel density and to analyze their effects according to glaucoma stage. STUDY

designRetrospective cross-sectional study.

methodsA total of 72 healthy eyes and 147 open-angle glaucomatous eyes were studied. All eyes underwent optical coherence tomography and visual field examinations. Clinical variables were compared according to the glaucoma stage. Relationships between macular vessel density (mVD) and other variables were analyzed using linear regression and segmented analyses.

resultsAge (P = 0.010) and signal strength (P < 0.001) were associated with macular vessel density in healthy eyes. In glaucomatous eyes, age, signal strength, ganglion cell-inner plexiform layer (GCIPL) thickness, and mean deviation (MD) correlated with macular vessel density (all P ≤ 0.005). When analyzed by glaucoma stage, age correlated with macular vessel density in early (P = 0.017 and all P ≤ 0.012, respectively) and moderate (P = 0.002 and all P ≤ 0.001, respectively) glaucoma. Conversely, GCIPL thickness was associated with macular vessel density (P = 0.004). According to segmented analysis between MD and mVD, the MD value at the change point for mVD was -17.92 dB, which was much lower than that for GCIPL thickness (-5.83 dB).

conclusionSignal strength was the most significant factor associated with macular vessel density in healthy and glaucomatous eyes. Other than signal strength, factors associated with macular vessel density of glaucomatous eyes vary according to the glaucoma stage. The segmented analysis suggests that mVD could be better than GCIPL thickness in predicting MD changes in moderate-to-advanced glaucoma.

Indexed as

GlaucomaTomography, Optical CoherenceAngiographyCross-Sectional StudiesHumansIntraocular PressureNerve FibersRetinal Ganglion CellsRetrospective StudiesGlaucomaMacular vessel densityOptical coherence tomography angiography

Identifiers

PMID32648073

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.