ArticleClinical oral investigations2021
Genetic variants in tooth agenesis-related genes might be also involved in tooth size variations.
Article in Clinical oral investigations, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 24 citations in OpenAlex.
- Investigating a potential association between agenesis of the third molars and variations in dental crown dimensions.PloS one · 2026Article
- Frequency and variability of nonmetric dental crown traits of primary and permanent molars in a group of orthodontic patients.Journal of orofacial orthopedics = Fortschritte der Kieferorthopadie : Organ/official journal Deutsche Gesellschaft fur Kieferorthopadie · 2025Observational
- Mandibular and dental measurements for sex determination using machine learning.Scientific reports · 2024Article
- Association between the severity of hypodontia and the characteristics of craniofacial morphology in a Chinese population: A cross-sectional study.Korean journal of orthodontics · 2023Article
- Article
- Comparative transcriptome profiles of human dental pulp stem cells from maxillary and mandibular teeth.Scientific reports · 2022Article
- Odontogenesis-related candidate genes involved in variations of permanent teeth size.Clinical oral investigations · 2021Article
- Article
- Quantum graph embedding of transcription factor-gene networks reveals key modules in periodontal bone inflammation: Comparative analysis of GAE and GAN.Journal of oral biology and craniofacial researchArticle
- Impact of FokI (rs2228570) and BglI (rs739837) polymorphisms inJournal of oral biology and craniofacial researchArticle
- Comparative evaluation of arch form among the Nepalese population: A morphological study.Journal of oral and maxillofacial pathology : JOMFPArticle
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveThe present study aimed to evaluate if genetic variants in PAX9, MSX1, TGFα, FGF3, FGF10, FGF13, GLI2 and GLI3 are involved in TS of permanent teeth. MATERIALS AND
methodsPretreatment dental records from orthodontic patients were assessed prior to recruitment. Patients with tooth agenesis and congenital anomalies (including oral cleft) and/or syndromes were excluded. Dental casts were used to measure the maximum crown dimensions of all fully erupted permanent teeth except second and third molars in mesiodistal direction. Teeth with caries, occlusal wear, mesiodistal restorations, and obvious deformities were not evaluated. Genomic DNA samples were used for genotyping. The allelic discrimination of 13 genetic variants was performed. The associations between TS and genotype were analyzed by linear regression, adjusted by gender at a significance level of p ≤ 0.05.
resultsGenetic polymorphisms in the tooth agenesis-related genes studied here were associated with increased and decreased TS, in both maxilla and mandible (p < 0.05).
conclusionThis study reported associations of novel tooth agenesis-related gene variants with permanent tooth size variations. CLINICAL RELEVANCE: The presence of some genetic variants could allow the prediction of permanent tooth size.
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