ArticleNeuroinformatics2021
MEArec: A Fast and Customizable Testbench Simulator for Ground-truth Extracellular Spiking Activity.
Article in Neuroinformatics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Article
- Efficient and reproducible pipelines for spike sorting large-scale electrophysiology data.eLife · 2026Article
- KIASORT: Knowledge-Integrated Automated Spike Sorting for Geometry-Free Neuron Tracking.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Spatial richness of neural magnetic fields.PLoS computational biology · 2026Article
- Benchmarking spike source localization algorithms in high density probes.PLoS computational biology · 2026Article
- A Scalable 1024-Channel Ultra-Low-Power Spike Sorting Chip with Event-Driven Detection and Spatial Clustering.IEEE journal of solid-state circuits · 2025Article
- Article
- Advances in large-scale electrophysiology with high-density microelectrode arrays.Lab on a chip · 2025Review
- Article
- Domain general noise reduction for time series signals with Noisereduce.Scientific reports · 2025Article
- Advancing Spike Sorting Through Gradient-Based Preprocessing and Nonlinear Reduction With Agglomerative Clustering.Brain and behavior · 2025Article
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- AECuration: automated event curation for spike sorting.Journal of neural engineering · 2025Article
- PseudoSorter: A self-supervised spike sorting approach applied to reveal Tau-induced reductions in neuronal activity.Science advances · 2025Article
- Article
- Unsupervised spike sorting for multielectrode arrays based on spike shape features and location methods.Biomedical engineering letters · 2024Article
- Spike sorting with Kilosort4.Nature methods · 2024Article
- A Modular Implementation to Handle and Benchmark Drift Correction for High-Density Extracellular Recordings.eNeuro · 2024Article
- Adaptive octree meshes for simulation of extracellular electrophysiology.Journal of neural engineering · 2023Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When recording neural activity from extracellular electrodes, both in vivo and in vitro, spike sorting is a required and very important processing step that allows for identification of single neurons' activity. Spike sorting is a complex algorithmic procedure, and in recent years many groups have attempted to tackle this problem, resulting in numerous methods and software packages. However, validation of spike sorting techniques is complicated. It is an inherently unsupervised problem and it is hard to find universal metrics to evaluate performance. Simultaneous recordings that combine extracellular and patch-clamp or juxtacellular techniques can provide ground-truth data to evaluate spike sorting methods. However, their utility is limited by the fact that only a few cells can be measured at the same time. Simulated ground-truth recordings can provide a powerful alternative mean to rank the performance of spike sorters. We present here MEArec, a Python-based software which permits flexible and fast simulation of extracellular recordings. MEArec allows users to generate extracellular signals on various customizable electrode designs and can replicate various problematic aspects for spike sorting, such as bursting, spatio-temporal overlapping events, and drifts. We expect MEArec will provide a common testbench for spike sorting development and evaluation, in which spike sorting developers can rapidly generate and evaluate the performance of their algorithms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.