ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2020
Factors associated with fracture after stroke and TIA: a long-term follow-up.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
- Neurology-Related Research Using the German Disease Analyzer Database: A Narrative Review of Studies Published Between 2020 and 2025.NeuroSci · 2026Review
- Gait Characteristics in Acute Stroke and Transient Ischemic Attack Measured with Accelerometers.Restorative neurology and neuroscience · 2025Article
- An exploration of serious falls after stroke using a large international stroke rehabilitation database.International journal of stroke : official journal of the International Stroke Society · 2025Article
- Association between stroke and fracture and the mediating role of depression: a cross-sectional study from NHANES 2017 to 2020.Frontiers in neurology · 2025Article
- Establishment and validation of a nomogram for predicting new fractures after PKP treatment of for osteoporotic vertebral compression fractures in the elderly individuals.BMC musculoskeletal disorders · 2023Article
- Hypnotics and injuries among older adults with Parkinson's disease: a nested case-control design.BMC geriatrics · 2023Article
- Heart Disease and Stroke Statistics-2023 Update: A Report From the American Heart Association.Circulation · 2023Review
- Comparison of the effectiveness of different machine learning algorithms in predicting new fractures after PKP for osteoporotic vertebral compression fractures.Journal of orthopaedic surgery and research · 2023Article
- Utilization of screening and treatment for osteoporosis among stroke survivors.Frontiers in endocrinology · 2022Article
- [Individual aspects in eldery patients with fragility fractures].Der Radiologe · 2021Review
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2 authors at 1 institution in 1 country.
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Abstract
We assessed the long-term incidence of fractures after stroke and TIA and analyzed associated factors. The fracture incidence increases with age and is higher in stroke than in TIA. Dementia is associated with fractures after both. Our results indicate tailored measures are necessary for preventing fractures after stroke or TIA.
introductionIn the present study, we aimed to assess the long-term incidence of fractures and analyze associated factors after stroke or transient ischemic attack (TIA).
methodsThe current cohort study included patients who had received an initial ischemic stroke or TIA diagnosis documented anonymously in the Disease Analyzer database (IQVIA) between 2000 and 2016 by physicians in 1262 general practices in Germany. Univariate Cox and multivariate regression models were carried out.
resultsThree groups (stroke, TIA, no stroke/TIA), each with 12,265 individuals, were selected (mean age 67.3 years, 48.1% female). A fracture was diagnosed in 12.9% of stroke patients and in 11.4% of TIA patients. Among male stroke patients, 11.1% had a fracture (15.4% among female stroke patients). The hazard ratio (HR) for fractures after stroke was 1.26 (CI: 1.15-1.39) and for fractures after TIA, it was 1.14 (CI: 1.03-1.25). In female stroke patients, the HR for fractures was 1.32 (CI: 1.15-1.60), while in males, it was 1.20 (CI: 1.03-1.39). Among TIA patients, females had an elevated HR for fractures (HR: 1.21; CI: 1.06-1.37). In individuals aged ≥ 80 years, an increased risk for fractures was only detected among TIA patients (HR: 1.26; CI: 1.05-1.51). Dementia and non-opioid analgesic therapy were positively associated with fracture after both stroke and TIA.
conclusionStroke was positively associated with fracture in patients < 80 years, while TIA was positively associated with fracture in patients ≥ 80 years and females. Dementia and analgesic therapy were also associated with fracture after either stroke or TIA.
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