Evidence map›Paper›PMID 32647755›Full record

ReviewKidney international reports2020

An Overview of Rickets in Children.

Rahul Chanchlani, Paul Nemer, Rajiv Sinha, Lena Nemer, Vinod Krishnappa, Etienne Sochett, Fayez Safadi, Rupesh Raina

Open access · goldAbstract readReview
In one paragraph

Review in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Trial
  4. Article
  5. Orthopaedist Beware: Severe Nutritional Rickets and Autism Spectrum Disorder.Journal of the Pediatric Orthopaedic Society of North America · 2026
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Dental disease burden and management in children and young people with X-linked hypophosphataemia: a scoping review and service evaluation.European archives of paediatric dentistry : official journal of the European Academy of Paediatric Dentistry · 2026
    Article
  11. Article
  12. Management of rickets: the new horizons for the pediatrician.Journal of health, population, and nutrition · 2025
    Review
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. The Importance of Determining the Level of Bone Metabolism Markers and Vitamin D in the First Year of Life in the Kazakh Population.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2024
    Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 3 countries.

Rahul ChanchlaniDivision of Pediatric Nephrology, Department of Pediatrics, McMaster Children's Hospital, Hamilton, Ontario, Canada.
Paul NemerAkron Nephrology Associates/Cleveland Clinic Akron General, Akron, Ohio, USA.
Rajiv SinhaDivision of Pediatric Nephrology, Institute of Child Health, Kolkata, India.
Lena NemerAkron Nephrology Associates/Cleveland Clinic Akron General, Akron, Ohio, USA.
Vinod KrishnappaAkron Nephrology Associates/Cleveland Clinic Akron General, Akron, Ohio, USA.
Etienne SochettDivision of Pediatrics Endocrinology, The Hospital for Sick Children, Toronto, Ontario, Canada.
Fayez SafadiDepartment of Anatomy and Neurobiology, Northeast Ohio Medical University, Rootstown, Ohio, USA.
Rupesh RainaAkron Nephrology Associates/Cleveland Clinic Akron General, Akron, Ohio, USA.
Akron General Medical Center · USAkron Children's Hospital · USCleveland Clinic · USHospital for Sick Children · CAImpact · CAInstitute of Child Health · INNortheast Ohio Medical University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rickets is a common bone disease worldwide that is associated with disturbances in calcium and phosphate homeostasis and can lead to short stature and joint deformities. Rickets can be diagnosed based on history and physical examination, radiological features, and biochemical tests. It can be classified into 2 major groups based on phosphate or calcium levels: phosphopenic and calcipenic. Knowledge of categorization of the type of rickets is essential for prompt diagnosis and proper management. Nutritional rickets is a preventable disease through adequate intake of vitamin D through both dietary and sunlight exposure. There are other subtypes of rickets, such as vitamin D-dependent type 1 rickets and vitamin D-dependent type 2 rickets (due to defects in vitamin D metabolism), renal rickets (due to poor kidney function), and hypophosphatemic rickets (vitamin D-resistant rickets secondary to renal phosphate wasting wherein fibroblast growth factor-23 (FGF-23) often plays a major role), which requires closer monitoring and supplementation with activated vitamin D with or without phosphate supplements. An important development has been the introduction of burosumab, a human monoclonal antibody to FGF-23, which is approved for the treatment of X-linked hypophosphatemia among children 1 year and older.

Indexed as

chronic kidney diseasehypocalcemiahypophosphatemiaphosphorusvitamin D

Identifiers

PMID32647755
PMCPMC7335963
OpenAlexW3015596351

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.