ArticleAnnals of translational medicine2020
Analysis of the clinical characteristics of 176 patients with pathologically confirmed cryptogenic organizing pneumonia.
Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 25 citations in OpenAlex.
- Multiple relapses of cryptogenic organizing pneumonia: A case report.Experimental and therapeutic medicine · 2026Article
- Characteristics, prognosis, and risk factors for relapse in patients with cryptogenic organizing pneumonia: A prospective cohort study in China.Chinese medical journal · 2026Article
- Oral corticosteroid dosing strategies for post-COVID-19 organising pneumonia: NORCOVID clinical trial.ERJ open research · 2026Article
- Rethinking treatment approaches to organising pneumonia: more lessons to be learned from COVID-19.ERJ open research · 2026Article
- Korean Guidelines for Diagnosis and Management of Interstitial Lung Disease: Cryptogenic Organizing Pneumonia.Tuberculosis and respiratory diseases · 2025Article
- Differences Between Patients with Probable UIP and Definite UIP on HRCT in Idiopathic Pulmonary Fibrosis: A Real-World Cohort Study.Journal of clinical medicine · 2024Article
- How I diagnose and treat organizing pneumonia in hematopoietic cell transplant recipients.Blood · 2024Review
- Cocaine-Induced Steroid Resistant Organising Pneumonia in a Young Male: The Lows of Getting High.Cureus · 2023Article
- Update on cryptogenic organizing pneumonia.Frontiers in medicine · 2023Review
- Article
- Cryptogenic organising pneumonia: current understanding of an enigmatic lung disease.European respiratory review : an official journal of the European Respiratory Society · 2021Review
- Systematic Review of Systemic Corticosteroids for Treatment of Organizing Pneumonia.Open respiratory archivesArticle
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10 authors at 2 institutions in 1 country.
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Abstract
backgroundCryptogenic organizing pneumonia (COP), is a form of idiopathic interstitial pneumonia (IIP) and is diagnosed by clinical-radiologic-pathologic (CRP) diagnosis. To summarize the clinical, imaging, pathological, and prognostic characteristics of 176 patients with confirmed COP.
methodsPatients who were diagnosed with organizing pneumonia (OP) by lung biopsy between January 1, 2000, and December 31, 2013, in our hospital were retrospectively analyzed and followed up until 12/31/2017. COP was confirmed by CRP diagnosis.
resultsA total of 1,346 OP cases were identified including 1,170 (86.9%) secondary OP cases (31 cases were originally misdiagnosed as COP but later confirmed as secondary OP during follow-up) and 176 (13.1%) cases of COP. The 176 patients with COP presented with no specific clinical symptoms and chest CT revealed diverse imaging features, such as patchy ground-glass opacity (112/176, 63.6%), consolidation (100/176, 56.8%), nodules (70/176, 39.8%), and fibrous stripes (69/176, 39.2%). The majority of patients (65.3%, 115/176) presented mixed patterns, and 12 (6.8%) showed a reversed halo sign. Of the 176 patients, 83 patients had unilateral lesions (ULs) and did not undergo glucocorticoid therapy. Of the 93 patients with bilateral lesions (BLs), 3 underwent complete resection and were radically cured. The other 90 patients underwent partial resection; of these patients, 37 cases achieved spontaneous remission, and 53 were treated with glucocorticoid therapy. After steroid therapy was reduced or stopped, 35 (66%) patients experienced recurrence. Overall, the 5-year survival rate for the COP patients in our study was 98.3%.
conclusionsOur study showed that the majority of the patients pathologically diagnosed as OP had secondary OP (86.9%), with COP accounting for only 13.9% of cases. CRP diagnosis and continuous follow-up may be the key for the accurate diagnosis of COP.
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